PROSPECT-C: A Study of Biomarkers of Response or Resistance to Anti-EGFR Therapies in Metastatic Colorectal Cancer
NCT02994888 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 47
Last updated 2016-12-19
Summary
PROSPECT-C is a phase II study investigating the molecular markers of response or resistance to anti-epidermal growth factor receptor (EGFR) antibodies.
Conditions
Interventions
- DRUG
-
All patients will be offered cetuximab 500mg/m2 every 2 weeks, until the time of progression
Sponsors & Collaborators
-
Royal Marsden NHS Foundation Trust
lead OTHER
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2012-11-30
- Primary Completion
- 2016-12-31
- Completion
- 2016-12-31
Countries
- United Kingdom
More Related Trials
-
Cetuximab + Best Supportive Care Compared With Best Supportive Care Alone in Metastatic Epidermal Growth Factor Receptor-Positive Colorectal Cancer
NCT00079066 ·Status: COMPLETED ·Phase: PHASE3
-
Cetuximab in Third Line for Mutant APC, TP53 and RAS Patients With Refractory Metastatic Colorectal Cancer
NCT04853043 ·Status: TERMINATED ·Phase: PHASE2
-
A Phase II Study of Cetuximab Plus Irinotecan in Patients With EGFR-detectable Metastatic Colorectal Carcinoma
NCT00362102 ·Status: COMPLETED ·Phase: PHASE2
-
Trial of Cetuximab in Patients With Metastatic and/or Locally Advanced Soft Tissue and Bony Sarcomas
NCT00148109 ·Status: COMPLETED ·Phase: PHASE2
-
Safety and Pharmacokinetics of Recombinant Anti-EGFr Antibody in Patients With Metastatic Colorectal Cancer
NCT03017807 ·Status: COMPLETED ·Phase: PHASE1
-
Cetuximab & Celecoxib for Metastatic Colorectal Cancer or Colorectal Cancer That Cannot Be Removed by Surgery
NCT00466505 ·Status: COMPLETED ·Phase: PHASE2
-
Pertuzumab and Cetuximab in Treating Patients With Previously Treated Locally Advanced or Metastatic Colorectal Cancer
NCT00551421 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Study of Erbitux (Cetuximab) in Patients With Metastatic Colorectal Carcinoma
NCT00044863 ·Status: COMPLETED ·Phase: PHASE2
-
Open-label Phase 1b Study of Ulixertinib and Cetuximab or Ulixertinib in Combination With Cetuximab and Encorafenib in Patients With Unresectable or Metastatic Colorectal Cancer Who Have Previously Received EGFR or BRAF-directed Therapy
NCT05985954 ·Status: RECRUITING ·Phase: PHASE1
-
Evaluating the Safety and Efficacy of SB Injection in Patients With Advanced or Metastatic Colorectal Cancer
NCT01305980 ·Status: UNKNOWN ·Phase: PHASE2
-
Cetuximab and Irinotecan in Treating Patients With Advanced Colorectal Cancer
NCT00005076 ·Status: COMPLETED ·Phase: PHASE2
-
Rechallenge of Cetuximab Combined With Irinotecan as Third-line Chemotherapy in Patients With Metastatic Colorectal Cancer - Phase II Study
NCT02316496 ·Status: TERMINATED ·Phase: PHASE2
-
Palbociclib and Cetuximab in Metastatic Colorectal Cancer
NCT03446157 ·Status: COMPLETED ·Phase: PHASE2
-
An Exploratory Pharmacogenomic Study of Monotherapy Erbitux in Subjects With Metastic Colorectal Cancer
NCT00207155 ·Status: COMPLETED ·Phase: PHASE1
-
Cetuximab and Envafolimab Plus mFOLFOXIRI as First-line Treatment for RAS/BRAF Wild-type, MSS, Unresectable Left-side Metastatic Colorectal Cancer
NCT05959356 ·Status: RECRUITING ·Phase: PHASE2
-
Cetuximab Monotherapy Maintenance Treatment in mCRC
NCT02978313 ·Status: UNKNOWN ·Phase: PHASE2/PHASE3
-
Cetuximab as Salvage Therapy in Patients With Neo Wild-type RAS/RAF Metastatic Colorectal Cancer With Liver Metastases.
NCT04189055 ·Status: UNKNOWN ·Phase: PHASE2
-
Prospective Translational Study Investigating Molecular Predictors of Resistance and Response to Regorafenib Monotherapy
NCT03010722 ·Status: COMPLETED
-
Cetuximab and Capecitabine in Treating Patients With Metastatic Colorectal Cancer That Failed Irinotecan Treatment
NCT00538291 ·Status: TERMINATED ·Phase: PHASE2
-
Study of Irinotecan and Cetuximab Versus Irinotecan as Second-Line Treatment in Patients With Metastatic, EGFR-Positive Colorectal Cancer
NCT00063141 ·Status: COMPLETED ·Phase: PHASE3
-
The Safety and Efficacy of Cetuximab Beta Plus Fruquintinib With or Without Immune Checkpoint Inhibitorrs in First-line Treatment of RAS/BRAF Wild Type Unresectable Metastatic Colorectal Cancer
NCT07257653 ·Status: RECRUITING ·Phase: PHASE2
-
Evaluating Panitumumab (ABX-EGF) Plus Best Supportive Care Versus Best Supportive Care in Patients With Metastatic Colorectal Cancer
NCT00113763 ·Status: COMPLETED ·Phase: PHASE3
-
Treatment After Irinotecan-based Frontline Therapy: Maintenance With Erbitux (in Patients wtRAS mCRC)
NCT02404935 ·Status: COMPLETED ·Phase: PHASE2
-
Study of Tumor Tissue Testing in Selecting Treatment for Patients With Metastatic or Locally Advanced Colorectal Cancer
NCT00975897 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Comparing Efficacy and Safety of Cetuximab (CinnaGen) Versus Erbitux® (Merck) in Metastatic Colorectal Cancer
NCT03391934 ·Status: RECRUITING ·Phase: PHASE3