Evaluation of Community-based Mass Screening and Treatment for Malaria in Western Kenya
NCT02987270 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 90000
Last updated 2016-12-09
Summary
This study is a cluster-randomized controlled trial to evaluate the efficacy of community-based mass screening with a malaria rapid diagnostic test, and treatment of participants with positive tests with an appropriate antimalarial for reducing malaria transmission indices.
Conditions
- Malaria,Falciparum
Interventions
- DRUG
-
Dihydroartemisinin-piperaquine
Dihydroartemisinin-piperaquine is an antimalarial in the artemisinin-based combination therapy class of drugs. It is the Kenya Ministry of Health second-line treatment for malaria in Kenya.
Sponsors & Collaborators
-
Centers for Disease Control and Prevention
collaborator FED -
Simon Kariuki
lead OTHER
Principal Investigators
-
Meghna R Desai, PhD · Centers for Disease Control and Prevention
-
Simon K Kariuki, PhD · Kenya Medical Research Institute
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2013-04-30
- Primary Completion
- 2015-08-31
- Completion
- 2015-08-31
More Related Trials
-
In-vivo Efficacy and Safety of Artemether/Lumefantrine Vs Dihydroartemisinin-piperaquine for Treatment of Uncomplicated Malaria and Assessment of Parasite Genetic Factors Associated With Parasite Clearance or Treatment Failure
NCT02590627 ·Status: COMPLETED ·Phase: PHASE4
-
Malaria as a Risk Factor for COVID-19 in Western Kenya and Burkina Faso
NCT04695197 ·Status: COMPLETED ·Phase: PHASE3
-
Mass Drug Administration of Ivermectin and Dihydroartemisinin-piperaquine as an Additional Intervention for Malaria Elimination
NCT03576313 ·Status: COMPLETED ·Phase: PHASE3
-
Phase 2 Efficacy Study of Primaquine and Methylene Blue
NCT02831023 ·Status: COMPLETED ·Phase: PHASE2
-
Effectiveness and Chemoprevention Efficacy of Implementing Seasonal Malaria Chemoprevention in Karamoja Region, Uganda
NCT05323721 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE4
-
Effectiveness of Mass Drug Administration for Reducing Seasonal Malaria Transmission in Zanzibar
NCT02721186 ·Status: COMPLETED ·Phase: NA
-
PDMC Implementation Trial in Kenya
NCT06624631 ·Status: RECRUITING ·Phase: PHASE4
-
Therapeutic Efficacy Study of AL and DP in Western Kenya
NCT05060198 ·Status: COMPLETED ·Phase: NA
-
Assessing the Efficacy of Artemisinin Combination Therapies for Treatment of Uncomplicated Malaria Infection in Children
NCT01082705 ·Status: COMPLETED ·Phase: PHASE3
-
Mass-Drug Administration to Reduce Malaria Transmission
NCT00509015 ·Status: COMPLETED ·Phase: NA
-
Dihydroartemisinin-piperaquine With Low Dose Primaquine to Reduce Malaria Transmission
NCT02259426 ·Status: COMPLETED ·Phase: PHASE3
-
Efficacy and Safety of Artemisinin-based Combination Treatments in the Democratic Republic of the Congo
NCT02940756 ·Status: COMPLETED ·Phase: PHASE4
-
Primaquine's Gametocytocidal Efficacy in Malaria Asymptomatic Carriers
NCT01838902 ·Status: COMPLETED ·Phase: PHASE3
-
Evaluation of 4 Artemisinin-based Combinations for Treating Uncomplicated Malaria in African Children
NCT00393679 ·Status: COMPLETED ·Phase: PHASE3
-
Assessing the Efficacy of Four Drug Combinations as the Next First-line Therapy for Uncomplicated Malaria in Malawi
NCT00164710 ·Status: COMPLETED ·Phase: PHASE4
-
Impact of Scaling up Mass Testing, Treatment and Tracking on Malaria Prevalence Among Children
NCT04167566 ·Status: COMPLETED ·Phase: NA
-
Malaria Diagnostic Testing and Conditional Subsidies to Target ACTs in the Retail Sector: TESTsmART Aim 2 - Kenya
NCT04428307 ·Status: COMPLETED ·Phase: NA
-
Use of Rapid Diagnostic Tests for Malaria Case Management in Kenya
NCT00336388 ·Status: COMPLETED ·Phase: NA
-
Epidemiology Study of Malaria Transmission Intensity in Africa
NCT01190202 ·Status: COMPLETED ·Phase: NA
-
Evaluation of the Efficacy of Artemisinin Combination Therapy in Kenya
NCT01899820 ·Status: UNKNOWN ·Phase: PHASE3
-
Mass Screening and Treatment for Reduction of Falciparum Malaria
NCT04093765 ·Status: COMPLETED ·Phase: NA
-
Reducing Malaria Transmission in Forest-going Mobile and Migrant Populations in Myanmar
NCT05025761 ·Status: UNKNOWN ·Phase: NA
-
Antimalaria Drugs Susceptibility Testing for an Effective Management of Infected Patients in Sub-Sahara Africa
NCT02974348 ·Status: COMPLETED ·Phase: PHASE3
-
Antimalarial Drug Resistance in Mali
NCT00127998 ·Status: COMPLETED ·Phase: NA
-
Malaria Therapeutic Efficacy Study (TES) Kenya
NCT04767191 ·Status: COMPLETED ·Phase: PHASE4