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Evaluation of Pesticide Exposure in the General Population

NCT02986763 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 166

Last updated 2018-02-09

No results posted yet for this study

Summary

An association has been suggested with several diseases including cancer and IARC has classified several pesticides as carcinogenic, probably carcinogenic. There is a need for a better characterisation of environmental pesticides exposures and identification of suitable biomarkers of exposure and effect. A better understanding of the impact of pesticide exposure on metabolomic, transcriptomic and epigenetic changes, is essential to strengthen epidemiological hypotheses on the association with several cancer types.

The main objective of the project is to validate a GIS (geographic information system) based method to assess environmental pesticide exposures, using environmental (contamination of housedust) and biological (blood and urine samples) measures. The project aims further to investigate a potential link between housedust contamination and biological measures in healthy non-smoking male residents and explore the impact of environmental pesticide exposure on metabolomics, transcriptomic and epigenetic parameters.

Conditions

  • Pesticide Poisoning

Interventions

BIOLOGICAL

Questionnaire, blood, urine, hair and dust samplings

Sponsors & Collaborators

  • Cancéropôle Lyon Auvergne Rhône-Alpes

    collaborator OTHER

  • International Agency for Research on Cancer

    collaborator OTHER

  • Rovaltain Research Company

    collaborator UNKNOWN

  • Centre de rechercher en Cancérologie de Lyon

    collaborator UNKNOWN

  • Centre Leon Berard

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-06-30
Primary Completion
2017-03-31
Completion
2017-03-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02986763 on ClinicalTrials.gov