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Applying Systems Immunology to the Search for Personalized Biomarkers of Clinical Efficacy

NCT02931955 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2020-05-20

No results posted yet for this study

Summary

Study Objective: Allergies affect up to 20% of the population of developed countries and can cause substantial individual disease burden. For some allergies, immunotherapeutic regimens ("hyposensitization") have been established, e.g. for insect venom allergies and pollen allergies. This project aims at identifying the T cell activation potential in vivo from resting T cells of patients undergoing immunotherapy (IT) via a systems biology approach. For the participants, it involves blood draws and stool collection as well as gathering some basic medical information. The participation takes one week for patients undergoing insect venom IT and three months for patients undergoing pollen IT. A control group without a clinical history of allergies is recruited. Blood and stool samples are collected in the same time frames as in allergic patients.

This study is a cooperation project between the Centre Hospitalier de Luxembourg (CHL), the Luxemburg Institute of Health (LIH), the University of Luxembourg and the Integrated Biobank of Luxemburg (IBBL).

Conditions

  • Allergy

Interventions

OTHER

Blood draw, stool collection.

Blood will be drawn by certified personnel according to local regulations. Stool will be collected by the patients after instructions on how to use a stool collection kit.

Sponsors & Collaborators

  • Integrated Biobank of Luxembourg

    collaborator OTHER

  • Centre Hospitalier du Luxembourg

    collaborator OTHER

  • Luxembourg Institute of Health

    lead OTHER_GOV

Principal Investigators

  • Markus Ollert, Prof. · Luxembourg Institute of Health

  • Feng Q He, PhD · Luxembourg Institute of Health

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-08-31
Primary Completion
2018-05-02
Completion
2019-07-31

Countries

  • Luxembourg

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02931955 on ClinicalTrials.gov