Combined Alternating Sunitinib and Bevacizumab (Avastin®) in Advanced Renal Cell Carcinoma (CASA)
NCT02919371 · Status: UNKNOWN · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 77
Last updated 2018-08-10
Summary
Combined sunitinib and bevacizumab in advanced renal cell carcinoma.
Conditions
Interventions
- DRUG
-
Sunitinib
Oral therapy ( Anti-vascular endothelial growth factor Tyrosin Kinase Inhibitor): given as 50 mg daily from day 1 to day 28- cycle repeated every 42 days
- DRUG
-
Monoclonal antibody against vascular endothelial growth factor: given intravenously on day 29 of each sunitinib cycle
Sponsors & Collaborators
-
King Faisal Specialist Hospital & Research Center
lead OTHER
Principal Investigators
-
Shouki Bazarbashi, MD · King Faisal Specialist Hospital & Research Center
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 85 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2014-12-31
- Primary Completion
- 2020-12-31
- Completion
- 2021-12-31
Countries
- Saudi Arabia
Study Locations
More Related Trials
-
A Phase I Study of Bevacizumab and Sunitinib in Metastatic Renal Cell Carcinoma Patients
NCT00421512 ·Status: COMPLETED ·Phase: PHASE1
-
An Open-Label Pharmacodynamic Study of Bevacivumab and Pazopanib in Renal Cell Carcinoma
NCT00992121 ·Status: COMPLETED ·Phase: PHASE1
-
Bevacizumab, Sorafenib Tosylate, and Temsirolimus in Treating Patients With Metastatic Kidney Cancer
NCT00378703 ·Status: COMPLETED ·Phase: PHASE2
-
A Study Evaluating Tarceva in Combination With Avastin Versus Avastin Alone in Treating Metastatic Renal Cell Carcinoma
NCT00081614 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Evaluate the Effectiveness of 5-Azacitidine and Bevacizumab in Advanced Renal Cell Carcinoma
NCT00934440 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
A Study of Avastin (Bevacizumab) Added to Interferon Alfa-2a (Roferon) Therapy in Patients With Metastatic Renal Cell Cancer With Nephrectomy
NCT00738530 ·Status: COMPLETED ·Phase: PHASE3
-
Capecitabine, Gemcitabine, and Bevacizumab in Combination for Patients With Sarcomatoid Renal Cell Carcinoma
NCT00496587 ·Status: COMPLETED ·Phase: PHASE2
-
OSI-774 and Bevacizumab in the Treatment of Patients With Metastatic Renal Cell Carcinoma
NCT00193154 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of Belzutifan (MK-6482) in Participants With Advanced Renal Cell Carcinoma (MK-6482-013)
NCT04489771 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Bevacizumab Plus Ixabepilone to Treat Patients With Advanced Kidney Cancer
NCT00923130 ·Status: COMPLETED ·Phase: PHASE2
-
Bevacizumab, Erlotinib, and Imatinib in the Treatment of Advanced Renal Cell Carcinoma
NCT00193258 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study of Atezolizumab (an Engineered Anti-Programmed Death-Ligand 1 [PD-L1] Antibody) as Monotherapy or in Combination With Bevacizumab (Avastin®) Compared to Sunitinib (Sutent®) in Participants With Untreated Advanced Renal Cell Carcinoma
NCT01984242 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011)
NCT04586231 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
A Study of Atezolizumab in Combination With Bevacizumab Versus Sunitinib in Participants With Untreated Advanced Renal Cell Carcinoma (RCC)
NCT02420821 ·Status: COMPLETED ·Phase: PHASE3
-
Vorinostat and Bevacizumab in Treating Patients With Unresectable or Metastatic Kidney Cancer
NCT00324870 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Combination of Temsirolimus and Bevacizumab in Patient With Metastatic Renal Cell Carcinoma
NCT00619268 ·Status: COMPLETED ·Phase: PHASE2
-
An Observational Study of Avastin (Bevacizumab) and Interferon Alpha 2a in Patients With Metastatic Renal Cell Cancer (VERA)
NCT01392729 ·Status: COMPLETED
-
Bevacizumab With or Without Sunitinib in Sunitinib-Refractory Renal Cell Carcinoma
NCT00556205 ·Status: WITHDRAWN ·Phase: PHASE2
-
Study of Patients With Metastatic and/or Advanced Renal Cell Carcinoma, Treated With Sunitinib/Axitinib.
NCT04033991 ·Status: COMPLETED
-
An Observational Chart Review Study To Describe The Real-World Outcomes And Use Of Avelumab In Combination With Axitinib For Treatment Of Patients With aRCC In The UK
NCT05394493 ·Status: COMPLETED
-
Pazopanib in Previously Treated Patients With Metastatic Renal Cell Carcinoma
NCT00731211 ·Status: COMPLETED ·Phase: PHASE2
-
Sequential Therapy in Metastatic Renal Cell Carinoma
NCT01731158 ·Status: COMPLETED ·Phase: PHASE2
-
Bortezomib and Bevacizumab ("BB-mib-mab") in Patients With Advanced or Recurrent Renal Cell Cancer (RCC)
NCT00184015 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Effects of Belzutifan on 89Zr-DFO-girentuximab PET Uptake in Patients With Renal Cell Carcinoma (RCC)
NCT07179770 ·Status: RECRUITING ·Phase: PHASE1
-
A Study of Bempegaldesleukin (NKTR-214: BEMPEG) in Combination With Nivolumab Compared With the Investigator's Choice of a Tyrosine Kinase Inhibitor (TKI) Therapy (Either Sunitinib or Cabozantinib Monotherapy) for Advanced Metastatic Renal Cell Carcinoma (RCC)
NCT03729245 ·Status: TERMINATED ·Phase: PHASE3