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Impact of Neutrophil Activation in Acute Ischemic Stroke Patients Treated With Endovascular Therapy

NCT02900833 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 440

Last updated 2026-01-20

No results posted yet for this study

Summary

Clinical and experimental data suggest that neutrophil activation and extravasation are deleterious in acute ischemic stroke (AIS) involving an increased risk of unfavorable outcome and hemorrhagic transformation (HT). However, clinical trials targeting neutrophil recruitment in AIS patients were negative. Recently, an experimental study has shown that neutrophil activation and transmigration begin immediately after the occlusion. Inhibition of neutrophil recruitment several hours after the start of ischemia appears therefore too late to have a clinical relevance.

The objective is to study the time dependent impact of neutrophils in AIS and the predominant mediators in each time point to identify the appropriate therapeutic target and time window.

Conditions

  • Acute Stroke

Sponsors & Collaborators

  • Fondation Ophtalmologique Adolphe de Rothschild

    lead NETWORK

Principal Investigators

  • Jean-Philippe DESILLES, MD · Fondation OPH A de Rothschild

  • Mikael MAZIGHI, MD, PhD · Fondation OPH A de Rothschild

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-03-24
Primary Completion
2022-12-12
Completion
2026-08-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02900833 on ClinicalTrials.gov