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The Effects of Prebiotics on Gut Bacterial Parameters, Immune Function & Exercise-Induced Airway Inflammation.

NCT02872675 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 17

Last updated 2020-09-09

No results posted yet for this study

Summary

The current study aims to explore the role of prebiotic supplementation in adults with and without Asthma/Exercise-Induced Bronchoconstriction (A/EIB). All participants will be asked to consume a prebiotic supplement, and a placebo, each for a total duration of four weeks, separated by a two-week wash out period. The investigators hypothesise that improvements in pulmonary function observed in adults with Asthma following prebiotic supplementation. We hypothesise that improvements in pulmonary function will be attributed, at least in part, to gut microbiota mediated improvements in human immune function.

Conditions

  • Exercised Induced Asthma
  • Asthma

Interventions

DIETARY_SUPPLEMENT

HOST-DM059

Experimental Supplement: HOST-DM059. Participants will be asked to orally consume one powdered sachet each day, at the same time in the morning, reconstituted in tea/coffee/fruit juice, or sprinkled over cereal etc. Whichever method of consumption is chosen, this must be kept consistent across both supplementation phases.

DIETARY_SUPPLEMENT

Maltodextrin

Placebo Comparator: Maltodextrin.

Sponsors & Collaborators

  • University of Reading

    collaborator OTHER

  • Clasado Biosciences

    collaborator UNKNOWN

  • Imperial College London

    collaborator OTHER

  • HOST Therabiomics

    collaborator UNKNOWN

  • The John van Geest Cancer Research Centre

    collaborator UNKNOWN

  • Nottingham Trent University

    lead OTHER

Principal Investigators

  • Graham R Sharpe, PhD · Nottingham Trent University

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-11-15
Primary Completion
2019-04-30
Completion
2019-04-30

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02872675 on ClinicalTrials.gov