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Effect of High Dose Vitamin D on Cancer Biomarkers and Breast Cancer Tumors

NCT02856503 · Status: WITHDRAWN · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL

Last updated 2026-04-17

No results posted yet for this study

Summary

High-doses of Vitamin D (VD) may be used as targeted therapy against breast cancer. The investigators will assess the effect of high dose VD on the following biomarkers in the breast cancer cells: VDR, estrogen receptor (ER), progesterone receptor (PR), epidermal growth factor receptor 2 (Her2/neu), androgen receptor (AR), as well as epidermal growth factor receptor 1 (EGFR) and Ki-67, as markers of proliferation, and E-cadherin, a marker of invasion and metastasis.

Conditions

  • Breast Cancer
  • Invasive Breast Carcinoma
  • Ductal Carcinoma In-situ

Interventions

DRUG

Vitamin D3

Weekly oral dose of Vitamin D3 per protocol.

Sponsors & Collaborators

  • Eli Avisar, MD

    lead OTHER

Principal Investigators

  • Eli Avisar, MD · University of Miami

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-01-13
Primary Completion
2023-01-31
Completion
2024-04-15
FDA Drug
Yes

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02856503 on ClinicalTrials.gov