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Characterization of Endothelial Dysfunction as a Function of Hyperaemia of the Brachial Artery During Cardiac Surgery

NCT02853682 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 28

Last updated 2018-08-21

No results posted yet for this study

Summary

The glycocalyx is a layer of proteins and complex sugars covering the endothelium of vessels. Its role as capillary filtration control is important. In case of alteration of the glycocalyx, experimental models and some clinical studies show an increased capillary leak responsible for interstitial edema. The analysis of glycocalyx in routine care is important to guide volume expansion. Indeed, the literature provides evidence about the poor prognosis of excess water and its impact on organ. This analysis challenge is to justify filling solution of choice according to the characteristic of this capillary leakage.

Conditions

  • Capillary Leak Syndrome

Interventions

BIOLOGICAL

plasma

assesment of glycocalyx protein

Sponsors & Collaborators

  • Centre Hospitalier Universitaire, Amiens

    lead OTHER

Principal Investigators

  • Osama ABOU ARAB, MD · CHU Amiens

  • Emmanuel LORNE, MD-PhD · CHU Amiens

  • Pierre-Gregoire GUINOT, MD · CHU Amiens

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-01-20
Primary Completion
2018-08-31
Completion
2018-08-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02853682 on ClinicalTrials.gov