Development of Ovarian Tissue Autograft in Order to Restore Ovarian Function
NCT02846064 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50
Last updated 2024-07-12
Summary
Ovarian cryopreservation is one of the available option for preserving fertility prior to potentially sterilizing treatments. In the absence of other techniques such as in vitro folliculogenesis or injection of isolated ovarian follicles, this tissue can only be re-used by autograft. In France, the first live birth after orthotopic ovarian transplantation, was obtained by Roux et al. in 2009. This clinical trial aims to collect data on the efficiency of the graft in terms of restoration of ovarian function and live births. It will also allow us to carry out the patient follow-up after ovarian tissue cryopreservation and after autograft when achieved. In cases of neoplastic malignancies, minimal residual disease detection will be performed on ovarian tissue, to avoid any risk of cancer re-seeding.
Conditions
- Ovarian Function Insufficiency
Interventions
- PROCEDURE
-
Autograft of cryopreserved ovarian tissue
Orthotopic transplantation
Sponsors & Collaborators
-
CHU de Reims
collaborator OTHER -
University Hospital, Marseille
collaborator OTHER -
Nantes University Hospital
collaborator OTHER -
University Hospital, Lille
collaborator OTHER -
Central Hospital, Nancy, France
collaborator OTHER -
University Hospital, Toulouse
collaborator OTHER -
University Hospital, Grenoble
collaborator OTHER -
University Hospital, Bordeaux
collaborator OTHER -
CMCO SIHCUS, Schiltingheim
collaborator OTHER -
University Hospital, Rouen
collaborator OTHER -
University Hospital, Limoges
collaborator OTHER -
University Hospital, Angers
collaborator OTHER_GOV -
Centre Hospitalier Universitaire de Nice
collaborator OTHER -
Tenon Hospital, Paris
collaborator OTHER -
Poissy-Saint Germain Hospital
collaborator OTHER -
Hôpital Jean Verdier
collaborator OTHER -
University Hospital, Clermont-Ferrand
collaborator OTHER -
Hopital Antoine Beclere
collaborator OTHER -
Centre Hospitalier Universitaire de Besancon
lead OTHER
Study Design
- Allocation
- NA
- Purpose
- OTHER
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 43 Years
- Sex
- FEMALE
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2013-10-31
- Primary Completion
- 2023-12-31
- Completion
- 2024-12-31
Countries
- France
Study Locations
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