Cognitive, Morphological and Neurobiological Progressive Aspects in Bipolar Disorders in the Elderly: Toward to a Neurodegenerescence Detection?

Summary

The purpose of this study is to identify association between cerebrospinal fluid Alzheimer's Disease's neurodegenerescence biomarkers (tau, ptau, Aß40 and Aß1-42) and occurrence of cognitive deficits in older patients with bipolar disorders.

Conditions

• Senile Plaques
• Tau Proteins
• Alzheimer Disease
• Bipolar Disorders
• Mild Cognitive Impairment

Interventions

PROCEDURE

Lombar Punction

cerebrospinal fluid testing at screening and M36

RADIATION

Magnetic Resonance Imaging (MRI)

MRI done at screening and M36

RADIATION

Positron-Emission Tomography (TEP) /(FDG)

TEP/FDG done at screening and M36

OTHER

Psychiatric tests

OTHER

Neuropsychological Tests

done at screening, M12, M24 and M36

GENETIC

Apolipoprotein (ApoE) detection

ApoE detection done at screening

Sponsors & Collaborators

• University Hospital, Tours

  collaborator OTHER

• Assistance Publique - Hôpitaux de Paris

  collaborator OTHER

• University Hospital, Marseille

  collaborator OTHER

• Hospices Civils de Lyon

  collaborator OTHER

• Centre Hospitalier Universitaire de Besancon

  collaborator OTHER

• Central Hospital, Nancy, France

  collaborator OTHER

• University Hospital, Clermont-Ferrand

  collaborator OTHER

• Versailles Hospital

  collaborator OTHER

• University Hospital, Montpellier

  collaborator OTHER

• Reims University hospital

  collaborator OTHER

• Centre Hospitalier Princesse Grace

  collaborator OTHER

• University Hospital, Grenoble

  lead OTHER

Principal Investigators

• BOUGEROL BT Thierry, Professor · University Hospital, Grenoble

Study Design

Allocation

NON_RANDOMIZED

Purpose

SCREENING

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

60 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-07-31

Primary Completion

2018-07-31

Completion

2018-07-31

Countries

• France

Study Locations