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The Impact of Alcohol Consumption on Tuberculosis Treatment Outcomes

NCT02840877 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 303

Last updated 2024-08-27

Study results available
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Summary

After HIV/AIDS, tuberculosis (TB) remains the second leading cause of death due to an infectious disease globally. Retrospective studies from many countries, including the United States and South Africa, have consistently reported that in addition to having a higher burden of TB disease, patients with problem alcohol use have worse TB treatment outcomes. This prospective study will attempt to clarify both behavioral and biologic causal mechanisms underlying the deleterious effects of problem alcohol use on TB treatment response.

Conditions

Interventions

BEHAVIORAL

DOT Adherence Monitoring

Study participants will meet with a study-employed DOT worker daily during weekdays throughout the course of their TB treatment

Sponsors & Collaborators

  • Medical Research Council, South Africa

    collaborator OTHER

  • Boston University

    collaborator OTHER

  • University of Cape Town

    collaborator OTHER

  • National Institute of Allergy and Infectious Diseases (NIAID)

    collaborator NIH

  • University of Stellenbosch

    collaborator OTHER

  • Boston Medical Center

    lead OTHER

Principal Investigators

  • Karen Jacobson, MD MPH · Boston Medical Center, Department of Medicine

Study Design

Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
15 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-05-16
Primary Completion
2022-06-28
Completion
2023-10-12

Countries

  • South Africa

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02840877 on ClinicalTrials.gov