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COmparison of MicroBiota AccordIng to Age in Crohn's Disease (COMeBACk)

NCT02839317 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 214

Last updated 2025-12-16

No results posted yet for this study

Summary

The cause of CD could be different according to age at onset of CD symptoms. Indeed we know that some very young patients at CD diagnosis have particular genetic variants as abnormalities of the IL10R that are regarded as quite monogenic disease. In the other way, the microbiota also undergoes substantial changes at the extremes of life, in infants and older people and the ramifications of which are very few being explored. The comparison of microbiota by principal component analysis and genetic profile of patients with CD beginning at the extremes of life could help us to better known physiopathology of CD according to age and provide arguments that CD beginning at the extremes of life could be different diseases.

The aim of the study is to ascertain through population-based study the hypothesis that gut microbiota is different between paediatric-onset and elderly-onset CD patients in relation with genetic and environmental mechanisms. The results will provide a better knowledge of the etiopathogenic ways in CD and propose a personalized therapeutic care based on age at CD onset (i.e. according to the gut bacteria involved).

Conditions

Interventions

BIOLOGICAL

Biological

comparison of microbiota, genetic profile between pediatric- and elderly-onset CD

Sponsors & Collaborators

  • National Research Agency, France

    collaborator OTHER

  • University Hospital, Lille

    lead OTHER

Principal Investigators

  • Corinne Gower-Rousseau, MD, PhD · University Hospital, Lille

Eligibility

Min Age
8 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-05-09
Primary Completion
2022-12-22
Completion
2022-12-22

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02839317 on ClinicalTrials.gov