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Trial on Radical Upfront Surgery in Advanced Ovarian Cancer

NCT02828618 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 797

Last updated 2025-10-03

No results posted yet for this study

Summary

This study consists of three parts, whereas Part 1 and Part 2 are performed in Germany only, and Part 3 is a multinational trial.

All patients with suspicion of advanced ovarian cancer are detected in the participating study centers in a pre-screening. The study centers will register all patients with suspected ovarian cancer in a screening log. After the patients have given informed consent, they can be enrolled in different parts of the study.

TRUST-Trial: This part compares two strategies in the therapy of advanced ovarian cancer. En detail, this part of the trial will evaluate if one of two strategies of timing surgery within the therapeutic procedures may show any significant advances in terms of overall survival over the other.

Conditions

Interventions

PROCEDURE

PDS (Primary Debulkdung Surgery)

PDS with maximum effort to achieve the goal of complete gross resection

PROCEDURE

6 cycles of standard chemotherapy

6 cycles of standard chemotherapy after Primary Debuling Surgery

PROCEDURE

Timing of surgery after 3 cycles of standard NACT, IDS

Timing of surgery after 3 cycles of standard NACT

PROCEDURE

IDS

IDS with maximum effort to achieve the goal of complete gross resection after NACT

DRUG

3 cycles of standard chemotherapy

3 more cycles (for a total of 6) of standard chemotherapy after IDS

Sponsors & Collaborators

  • AGO Study Group

    lead OTHER

Principal Investigators

  • Sven Mahner, Professor MD · AGO Study Group

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-07-31
Primary Completion
2025-02-28
Completion
2025-12-31

Countries

  • United States
  • Austria
  • Denmark
  • France
  • Germany
  • Italy
  • Sweden
  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02828618 on ClinicalTrials.gov