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High Resolution Donor Recipient HLA Matching Level in Unrelated HSCT

NCT02827149 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 1838

Last updated 2021-08-20

No results posted yet for this study

Summary

Italian, retrospective, prospective, observational, multicentre, spontaneous, non-interventional, non-pharmacological The study aims to analyze in the national Italian experience

1. The compatibility level selected by the Italian Transplant Centres using an high resolution HLA typing at the start of search process for hematopoietic stem cell transplantation from volunteer unrelated donor
2. The transplant outcomes in terms of Overall Survival, Disease Free Survival, Relapse Rate and Transplant Related Mortality and the correlation with the level of HLA matching pairs of donor/recipient included in the Italian Bone Marrow Donor Registry and Promise registry.
3. The possible identification of allelic mismatching combinations characterized by increased cross-reactivity associated with higher incidence of acute or chronic graft-versus-host disease .
4. The possible identification of combinations of allelic mismatching characterized by higher permissiveness.

Conditions

Sponsors & Collaborators

  • Associazione Italiana di Immunogenetica e Biologia dei Trapianti (AIBT)

    collaborator UNKNOWN

  • National Marrow Donor Program

    collaborator OTHER

  • University of Rome Tor Vergata

    collaborator OTHER

  • Gruppo Italiano Trapianto di Midollo Osseo

    lead OTHER

Principal Investigators

  • Alessandra Picardi, MD · Policlinico Università Tor Vergata - Rome

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-09-01
Primary Completion
2018-09-01
Completion
2018-09-21

Countries

  • Italy

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02827149 on ClinicalTrials.gov