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The Influence of High and Low Salt on Exosomes in the Urine

NCT02823613 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2020-04-07

No results posted yet for this study

Summary

The hypothesis is that changes in the epithelial sodium channel (ENaC) in the kidney is reflected in urinary exosomes and that the amount of ENaC as well as the cleavage degree is upregulated in conditions with low salt.

Conditions

  • Healthy

Interventions

DIETARY_SUPPLEMENT

High salt diet followed by low salt diet

High salt diet (250 mmol/day) in 5 days followed by low salt diet (60-70 mmol/day) in 5 days.

DIETARY_SUPPLEMENT

Low salt diet followed by high salt diet

Low salt diet (60-70 mmol/day) in 5 days followed by high salt diet (250 mmol/day) in 5 days.

Sponsors & Collaborators

  • Danish Diabetes Academy

    collaborator OTHER

  • Odense University Hospital

    collaborator OTHER

  • Beckett Foundation

    collaborator OTHER

  • University of Southern Denmark

    lead OTHER

Principal Investigators

  • Boye L Jensen, dr.med., phd · Cardiovascular and Renal Research, Institute of Moleculare Medicine, University of Southern Denmark

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
20 Years
Max Age
40 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-08-31
Primary Completion
2019-05-01
Completion
2019-05-23

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02823613 on ClinicalTrials.gov