A Study of T-VEC (Talimogene Laherparepvec) With or Without Radiotherapy for Melanoma, Merkel Cell Carcinoma, or Other Solid Tumors
NCT02819843 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 19
Last updated 2025-01-29
Summary
The purpose of this phase II clinical study is to test the good and bad effects of T-VEC (talimogene laherparepvec) with or without hypofractionated radiotherapy on people with melanoma, Merkel cell carcinoma, or other solid tumors with skin metastasis.
Conditions
- Melanoma
- Merkel Cell Carcinoma
- Other Solid Tumors
Interventions
- DRUG
-
TALIMOGENE LAHERPAREPVEC (TVEC)
- RADIATION
-
Hypofractionated Radiotherapy
Sponsors & Collaborators
- collaborator INDUSTRY
-
Memorial Sloan Kettering Cancer Center
lead OTHER
Principal Investigators
-
Christopher Barker, MD · Memorial Sloan Kettering Cancer Center
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2016-06-21
- Primary Completion
- 2024-02-22
- Completion
- 2024-02-22
Countries
- United States
Study Locations
More Related Trials
-
Expanded Access Study of Talimogene Laherparepvec for Treatment of Subjects With Unresected Stage IIIB-IVM1c Melanoma
NCT02297529 ·Status: NO_LONGER_AVAILABLE
-
Expanded Access Protocol of Talimogene Laherparepvec for Subjects With Unresected, Stage lllB to IVM1c Melanoma
NCT02147951 ·Status: NO_LONGER_AVAILABLE
-
An Extension Protocol for the Extended Use of Talimogene Laherparepvec for Eligible Patients Who Participated in Study 002/03 (NCT00289016)
NCT02574260 ·Status: COMPLETED ·Phase: PHASE2
-
Efficacy and Safety of Talimogene Laherparepvec Neoadjuvant Treatment Plus Surgery Versus Surgery Alone for Melanoma
NCT02211131 ·Status: COMPLETED ·Phase: PHASE2
-
An Extended Use Study of Safety and Efficacy of Talimogene Laherparepvec in Melanoma
NCT01368276 ·Status: COMPLETED ·Phase: PHASE3
-
Talimogene Laherparepvec and Pembrolizumab in Treating Patients With Stage III-IV Melanoma
NCT02965716 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Study of Talimogene Laherparepvec in Stage IIIc and Stage IV Malignant Melanoma
NCT00289016 ·Status: COMPLETED ·Phase: PHASE2
-
Neoadjuvant Combination Immunotherapy for Stage III Melanoma
NCT03842943 ·Status: RECRUITING ·Phase: PHASE2
-
A Phase II Study of Single Agent MEK162 in Patients With Advanced Melanoma
NCT01320085 ·Status: COMPLETED ·Phase: PHASE2
-
PV-10 vs Chemotherapy or Oncolytic Viral Therapy for Treatment of Locally Advanced Cutaneous Melanoma
NCT02288897 ·Status: TERMINATED ·Phase: PHASE3
-
Phase 2 Study of Intralesional PV-10 for Metastatic Melanoma
NCT00521053 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase II Trial of PD-L1 Therapy Combined With Anti-VEGF Therapy in Unresectable or Metastatic Melanoma
NCT04356729 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Study Comparing Combination of LGX818 Plus MEK162 Versus Vemurafenib and LGX818 Monotherapy in BRAF Mutant Melanoma
NCT01909453 ·Status: COMPLETED ·Phase: PHASE3
-
Imatinib Mesylate and Bevacizumab in Treating Patients With Advanced Melanoma or Other Advanced Cancers
NCT00074308 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Comparison of eBX and Mohs Surgery for Treatment of Early-stage Non-melanoma Skin Cancer a Matched Pair Cohort Study.
NCT03024866 ·Status: COMPLETED
-
Ipilimumab With or Without Talimogene Laherparepvec in Unresected Melanoma
NCT01740297 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
TNFerade™ Biologic Plus Radiation for Metastatic Melanoma
NCT00261404 ·Status: COMPLETED ·Phase: PHASE2
-
Phase II Study to Assess the Safety and Immunogenicity of recMAGE-A3+AS15 ASCI With or Without Poly IC:LC
NCT01437605 ·Status: TERMINATED ·Phase: PHASE2
-
Photodynamic Therapy in Treating Patients With Stage III or Stage IV Melanoma
NCT00007969 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Temsirolimus and Bevacizumab in Treating Patients With Stage III or Stage IV Malignant Melanoma
NCT00397982 ·Status: COMPLETED ·Phase: PHASE2
-
RTA 408 Capsules in Patients With Melanoma - REVEAL
NCT02259231 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of Investigational Treatments in Combination With Standard of Care Immune Checkpoint Inhibitors in Participants With Advanced Melanoma
NCT02723006 ·Status: TERMINATED ·Phase: PHASE1
-
Intralesional PV-10 Chemoablation of Metastatic Melanoma
NCT00219843 ·Status: COMPLETED ·Phase: PHASE1
-
A Prospective Observational Study on Targeted Therapy for Unresectable or Metastatic BRAFV600E Mutant Melanoma Patients
NCT04911998 ·Status: COMPLETED
-
Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)
NCT05549297 ·Status: RECRUITING ·Phase: PHASE3