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Targeting the Mechanisms Underlying Cutaneous Neurofibroma Formation in NF1: A Clinical Translational Approach.

NCT02777775 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 71

Last updated 2025-07-24

No results posted yet for this study

Summary

The purpose of the research study is intended to use specimens (such as tissue) and medical information in the Laboratory of Musculoskeletal Oncology at the Van Andel Research Institute for laboratory research in Grand Rapids, Michigan. Small tissue samples of cutaneous neurofibromas will be collected as part of this research. The samples will help researchers learn more about cutaneous neurofibroma and help them better understand NF1. There are many different types of studies, both now and in the future, that can be done using the specimens the investigators receive. These include using the specimens and information to look for new ways to diagnose and treat Neurofibromatosis Type 1 (NF1). The specimens may be used to study how genes affect health and disease, or how genes affect the way a disease or condition responds to treatment. Some of these studies may lead to new products, such as treatments or tests for diseases. Through this study, the investigators hope to find better ways to understand and treat NF1 in the future.

Conditions

  • Cutaneous Neurofibromas
  • Neurofibromatosis Type 1
  • Plexiform Neurofibromas

Interventions

PROCEDURE

Skin Biopsy

The procedure to sample the cutaneous neurofibroma involves a skin incision and will take approximately 10 to 15 minutes. The tissue will be taken in the following way: * The skin area will be cleaned * The skin area will be numbed (by either a numbing cream or a tiny numbing shot) * Cutaneous (skin) Neurofibroma: will be taken via a small incision and removal of the neurofibroma whenever possible. * A small piece of normal (skin) tissue will be numbed as above and taken using a special skin biopsy device. Afterward, the area will be cleaned and the skin put back together with medical super glue or 1 to 2 dissolvable stitches that will dissolve as the incision heals, they do not require removal. The purpose of taking this piece of skin is to compare normal skin with the skin of a cutaneous neurofibroma.

Sponsors & Collaborators

  • Van Andel Research Institute

    collaborator OTHER

  • Spectrum Health Hospitals

    lead OTHER

Principal Investigators

  • Matthew R Steensma, MD · Spectrum Health Hospitals

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-05-31
Primary Completion
2025-06-30
Completion
2025-06-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02777775 on ClinicalTrials.gov