Resource Sparing Curative Radiotherapy for Locally Advanced Squamous Cell Cancer of the Head and Neck: The HYPNO Trial
NCT02765503 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 836
Last updated 2019-08-08
Summary
The aim of the study is to test whether a resource-sparing 4-week, 20-fraction course of accelerated hypofractionated radiotherapy is non-inferior to accelerated radiotherapy delivering 33 fractions over 5.5 weeks in the treatment of patients with Stage I-IV squamous cell carcinoma of the pharynx, larynx and oral cavity with the exception of paranasal sinus, nasopharyngeal and stage I-II glottic carcinomas.
Conditions
- Squamous Cell Carcinoma of the Head and Neck
Interventions
- RADIATION
-
External beam radiotherapy
External beam radiotherapy using megavoltage radiotherapy with radical intent.
Sponsors & Collaborators
-
Centro de Lucha contra el Cáncer, Montevideo, Uruguay
collaborator UNKNOWN -
Institute Rotary Cancer Hospital, New Delhi, India
collaborator UNKNOWN -
Tata Memorial Centre
collaborator OTHER -
Bahawalpur Institute of Nuclear Medicine and Oncology, Bahawalpur, Pakistan
collaborator UNKNOWN -
GKNM Hospital, Tamil Nadu, India
collaborator UNKNOWN -
Fundacion Escuela de Medicina Nuclear, Mendoza, Argentina
collaborator UNKNOWN -
Instituto de Oncología y Radiobiología, Havana, Cuba
collaborator UNKNOWN -
University of Indonesia, Jakarta, Indonesia
collaborator UNKNOWN -
St Luke's Medical Centre, Quezon City, Manilla, Phillippines
collaborator UNKNOWN -
University of Pretoria, Pretoria, South Africa
collaborator UNKNOWN -
Mahidol University
collaborator OTHER -
University of Maryland, College Park
collaborator OTHER -
Barretos Cancer Hospital, Barretos, Brazil
collaborator UNKNOWN -
International Atomic Energy Agency
lead OTHER_GOV
Principal Investigators
-
Soren Bentzen · University of Maryland, College Park
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2014-03-31
- Primary Completion
- 2020-11-30
- Completion
- 2021-11-30
Countries
- Argentina
- Cuba
- India
- Indonesia
- Pakistan
- Philippines
- South Africa
- Thailand
- Uruguay
Study Locations
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