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Heterologous Effect of Diptheria, Tetanus, Acellular Pertussis Vaccination on Influenza Challenge in the Elderly

NCT02765126 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 450

Last updated 2017-07-27

No results posted yet for this study

Summary

Vaccines can have non-targeted or heterologous (also called non-specific) immunological effects on the immune system i.e. effects other than inducing an immune response against the disease targeted by the vaccine. This trial aims to evaluate the non-specific immunological effects of two vaccines - diphtheria-tetanus-acellular pertussis (DTP) vaccine and seasonal influenza vaccine - in a cohort of elderly humans (\>65 years of age) and healthy adult control subjects (30-50 years).

Conditions

  • Heterologous Effects of Vaccines

Interventions

BIOLOGICAL

Seasonal influenza vaccine

Intramuscular standard seasonal influenza vaccine

BIOLOGICAL

Diphtheria-tetanus-acellular pertussis vaccine

Intramuscular DTaP vaccine

Sponsors & Collaborators

  • Monash University

    collaborator OTHER

  • The Peter Doherty Institute for Infection and Immunity

    collaborator OTHER

  • University of Sao Paulo

    collaborator OTHER

  • Johns Hopkins Bloomberg School of Public Health

    collaborator OTHER

  • Clifford Craig Medical Research Trust

    lead OTHER

Principal Investigators

  • Katie Flanagan, PhD FRACP · Clifford Craig Medical Research Trust

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-05-31
Primary Completion
2019-12-31
Completion
2019-12-31

Countries

  • Australia

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02765126 on ClinicalTrials.gov