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Evaluation of Serum Amyloid A in Early Diagnosis of Spontaneous Bacterial Peritonitis

NCT02759497 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2017-06-20

No results posted yet for this study

Summary

One of the most common and serious complications in decompensated cirrhotic patients (DCPs) is bacterial infection.The most common infections in DCPs are cases of spontaneous bacterial peritonitis (SBP), which account for 40% 70% of cases, followed by urinary tract infections, pneumonia and cellulitis.

Serum amyloid A (SAA) and C-reactive protein (CRP) are acute-phase proteins predominantly produced and secreted by hepatocytes. Other cells including lymphocytes, monocytes, and macrophages can also produce these proteins. The induction of SAA and CRP synthesis is triggered by a number of cytokines, chiefly IL-6, which is released from a variety of cell types, but mainly from macrophages and monocytes at inflammatory sites

Conditions

  • Spontaneous Bacterial Peritonitis

Interventions

OTHER

serum amyloid A level

serum amyloid A level (SAA)

Sponsors & Collaborators

  • Tanta University

    lead OTHER

Principal Investigators

  • Rehab Badawi, Consultant · Hepatology and gastroenterology dept.-Tanta

  • Sherief Abd-Elsalam, Consultant · Division of Gastroenterology and Hepatology- Tanta

  • Walaa Elkhalawany, Consultant · Hepatology and gastroenterology dept.-Tanta

  • Reham Elkhouly, Consultant · Hepatology and gastroenterology dept.-Tanta

  • Mona Watany, Consultant · clinical pathology dept.-Tanta

  • Samah Soliman, Consultant · Hepatology and gastroenterology dept.-Tanta

  • Mai Khalaf, resident · hepatology dept.-Tanta

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-03-31
Primary Completion
2020-10-31
Completion
2020-11-30

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02759497 on ClinicalTrials.gov