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Impact of Allo- and Autoantibodies on Chronic Cardiac Allograft Function

NCT02752789 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 407

Last updated 2019-11-29

No results posted yet for this study

Summary

This is a multi-center, prospective, single cohort, observational study of pediatric heart transplant recipients designed to determine the impact of preformed versus de novo human leukocyte antigen (HLA) donor-specific antibodies (DSA), and antibodies to the self-antigens cardiac myosin and vimentin, on chronic allograft function. In addition, the investigators will explore mechanisms of action and predictors of DSA, rejection and altered pathophysiology.

Conditions

  • Pediatric Heart Transplantation
  • Pediatric Heart Transplant Recipients

Sponsors & Collaborators

  • Clinical Trials in Organ Transplantation in Children

    collaborator OTHER

  • National Institute of Allergy and Infectious Diseases (NIAID)

    lead NIH

Principal Investigators

  • Steven A. Webber, MBChB, MRCP · Monroe Carell Jr. Children's Hospital at Vanderbilt: Pediatric Transplantation

  • Steven A. Webber, MBChB, MRCP · Monroe Carell Jr. Children's Hospital at Vanderbilt: Pediatric Transplantation

Eligibility

Max Age
20 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-07-15
Primary Completion
2019-11-01
Completion
2019-11-01

Countries

  • United States
  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02752789 on ClinicalTrials.gov