Immune Predictors of Response to Pembrolizumab Therapy in Stage IV Melanoma Patients
NCT02744209 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 17
Last updated 2019-11-07
Summary
This study will test whether immune functions in individual cancer patients can be characterized in a quantitative manner using new technologies that analyze nucleic acids from peripheral blood cells and whether those quantitations can be used to predict the response outcomes of patients being treated with Pembrolizumab.
Conditions
- Stage IV Melanoma
Sponsors & Collaborators
- collaborator INDUSTRY
- lead OTHER
Principal Investigators
-
Larry R Pease, Ph.D. · Mayo Clinic
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2016-04-30
- Primary Completion
- 2019-01-31
- Completion
- 2019-01-31
Countries
- United States
Study Locations
More Related Trials
-
Pembrolizumab and Imatinib in Patients With Locally Advanced/Metastatic Melanoma With c-KIT Mutation/Amplification
NCT02812693 ·Status: WITHDRAWN ·Phase: PHASE1/PHASE2
-
Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of Investigational Treatments in Combination With Standard of Care Immune Checkpoint Inhibitors in Participants With Advanced Melanoma
NCT02723006 ·Status: TERMINATED ·Phase: PHASE1
-
Talimogene Laherparepvec and Pembrolizumab in Treating Patients With Stage III-IV Melanoma
NCT02965716 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Neoadjuvant Pembrolizumab for Unresectable Stage III and Unresectable Stage IV Melanoma
NCT02306850 ·Status: COMPLETED ·Phase: PHASE2
-
A Study to Compare the Administration of Pembrolizumab After Surgery Versus Administration Both Before and After Surgery for High-Risk Melanoma
NCT03698019 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Evaluation of Anti-PD-1 Therapy by Monitoring T Cell Responses in Melanoma, Lung and Other Cancer Types
NCT06075524 ·Status: RECRUITING
-
Trial of Pembrolizumab and Radiotherapy in Melanoma
NCT02562625 ·Status: TERMINATED ·Phase: PHASE2
-
Imaging FDG Flare in Melanoma
NCT02791594 ·Status: COMPLETED
-
A Phase II Study of Neoadjuvant Pembrolizumab & Lenvatinib for Resectable Stage III Melanoma
NCT04207086 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
PV-10 in Combination With Pembrolizumab for Treatment of Metastatic Melanoma
NCT02557321 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.
NCT05727904 ·Status: RECRUITING ·Phase: PHASE3
-
A Phase 2 Biomarker - Enriched Study of TH-302 in Subjects With Advanced Melanoma
NCT01864538 ·Status: TERMINATED ·Phase: PHASE2
-
Pembrolizumab Effects on NK Cell Exhaustion in Melanoma (Merck NK-IIT)
NCT03241927 ·Status: TERMINATED ·Phase: PHASE2
-
SX-682 Treatment in Subjects With Metastatic Melanoma Concurrently Treated With Pembrolizumab
NCT03161431 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Study of Neoadjuvant Imprime PGG and Pembrolizumab for Stage III, Resectable Melanoma
NCT04995094 ·Status: WITHDRAWN ·Phase: PHASE2
-
A Phase II Trial of Neoadjuvant Treatment With PD-1 Inhibition (Nivolumab) With or Without IDO Inhibition (BMS-986205) and With or Without CTLA-4 Inhibition (Ipilimumab) in Resectable Stage III or IV Melanoma
NCT04007588 ·Status: WITHDRAWN ·Phase: PHASE2
-
Using Biomarkers to Help Guide Safe Immunotherapy Discontinuation in Patients With Unresectable Stage IIIB-IV Melanoma, The PET-Stop Trial
NCT04462406 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Dose-seeking Study of Pembrolizumab Plus Vemurafenib and Cobimetinib Advanced Melanoma
NCT02818023 ·Status: TERMINATED ·Phase: PHASE1
-
Talimogene Laherparepvec With Pembrolizumab in Melanoma Following Progression on Prior Anti-PD-1 Based Therapy (MASTERKEY-115) (Mk-3475-A07/KEYNOTE-A07).
NCT04068181 ·Status: COMPLETED ·Phase: PHASE2
-
Aldesleukin Imaging in Viewing Tumor Growth in Patients With Stage IV Melanoma Receiving Ipilimumab or Pembrolizumab Therapy
NCT01789827 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Profiling of Circulating Immune Cells to Uncover Response Signatures to Anti-PD1 Immunotherapy in Melanoma Patients
NCT06154668 ·Status: RECRUITING
-
Pembrolizumab and Hypofractionated Stereotactic Radiotherapy in Patients With Malignant Pleural Mesothelioma
NCT04166734 ·Status: TERMINATED ·Phase: PHASE1
-
Study of IDO Inhibitor in Combination With Checkpoint Inhibitors for Adult Patients With Metastatic Melanoma
NCT02073123 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Immunotherapy Study for Patients With Stage IV Melanoma
NCT02054520 ·Status: TERMINATED ·Phase: PHASE2
-
Pembrolizumab With Talimogene Laherparepvec or Placebo in Unresected Melanoma
NCT02263508 ·Status: TERMINATED ·Phase: PHASE3