Development of a Nutrigenetic Test for Personalized Prescription of Body Weight Loss Diets (Obekit)

Summary

This study evaluates the relationship between several genetic variants and the response to a hypocaloric diet, in order to design a genetic test which permits prescribe the more personalized diet for each individual according to her genotype. Half of the participants will assigned to a moderate high protein diet, while the other half will assigned to a high carbohydrate diet.

Conditions

• Body Weight Changes

Interventions

BEHAVIORAL

Moderately high protein diet

After the recruitment randomization of the study participants, the study will consists of a 4-month nutritional intervention ("body weight loss period") followed by a second 6-month period ("body weight maintenance period") in which the subjects of the study will continue with the assigned diet, but without any energy restriction.

BEHAVIORAL

Low fat diet

After the recruitment randomization of the study participants, the study will consists of a 4-month nutritional intervention ("body weight loss period") followed by a second 6-month period ("body weight maintenance period") in which the subjects of the study will continue with the assigned diet, but without any energy restriction.the energy derived from fat

Sponsors & Collaborators

• Clinica Universidad de Navarra, Universidad de Navarra

  lead OTHER

Principal Investigators

• J. Alfredo Martínez, MD, PhD · Centre for Nutrition Research, University of Navarra. CIBER Obesity and Physiopathology of Nutrition (CIBERobn), Institute of Health Carlos III Madrid Spain

• Fernando J. Corrales, PhD · CIMA, University of Navarra

• Femín I Milagro, PhD · Centre for Nutrition Research, University of Navarra. CIBER Obesity and Physiopathology of Nutrition (CIBERobn), Institute of Health Carlos III Madrid Spain

• Jose Ignacio Riezu, PhD · Centre for Nutrition Research, University of Navarra

• Carlos González-Navarro, PhD · Centre for Nutrition Research, University of Navarra

• Marta Cuervo, PhD · Centre for Nutrition Research, University of Navarra

• Iosune Zubieta · Centre for Nutrition Research, University of Navarra

• Blanca Esther Martínez de Morentin, MD · Centre for Nutrition Research, University of Navarra

• Leticia Goñi · Centre for Nutrition Research, University of Navarra

• Santiago Navas, PhD · Centre for Nutrition Research, University of Navarra. CIBER Obesity and Physiopathology of Nutrition (CIBERobn), Institute of Health Carlos III Madrid Spain

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2015-11-30

Primary Completion

2017-12-31

Completion

2017-12-31

Countries

• Spain

Study Locations