A Study of Galunisertib (LY2157299) and Durvalumab (MEDI4736) in Participants With Metastatic Pancreatic Cancer
NCT02734160 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 37
Last updated 2019-08-05
Summary
The main purpose of this study is to evaluate the safety and efficacy of the study drug known as galunisertib administered in combination with the anti-programmed cell death-ligand 1 (PD-L1) antibody durvalumab in participants with refractory metastatic pancreatic cancer.
Conditions
Interventions
- DRUG
-
Galunisertib
Administered orally
- DRUG
-
Administered IV
Sponsors & Collaborators
- collaborator INDUSTRY
- lead INDUSTRY
Principal Investigators
-
Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST) · Eli Lilly and Company
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2016-06-15
- Primary Completion
- 2018-08-02
- Completion
- 2019-04-17
Countries
- United States
- France
- Italy
- South Korea
- Spain
Study Locations
More Related Trials
-
Study of Effect of Azeliragon in Patients Refractory to Prior Treatment of Metastatic Pancreatic Cancer
NCT05766748 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Durvalumab and "Booster" Radiation in Metastatic Adenocarcinoma of the Pancreas
NCT03490760 ·Status: TERMINATED ·Phase: PHASE2
-
Dasatinib in Treating Patients With Metastatic Pancreatic Cancer
NCT00474812 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase 1B Study of Canakinumab, Spartalizumab, Nab-paclitaxel, and Gemcitabine in Metastatic Pancreatic Cancer (PC) Patients
NCT04581343 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of Durvalumab in Patients With BR PDA Following Neoadjuvant Therapy and Successful Surgical Resection
NCT03038477 ·Status: WITHDRAWN ·Phase: PHASE2
-
Olaparib and Durvalumab (MEDI4736) in Patients with Metastatic Pancreatic Cancer and DNA Damage Repair Genes Alterations
NCT05659914 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Phase II Study to Evaluate GFH375 in Patients With KRAS G12D Mutant Metastatic Pancreatic Cancer
NCT07026916 ·Status: WITHDRAWN ·Phase: PHASE2
-
Regorafenib Plus Gemcitabine in Metastatic Pancreatic Cancer
NCT02383433 ·Status: TERMINATED ·Phase: PHASE2
-
Efavirenz as Second-Line Therapy in Treating Patients With Metastatic Pancreatic Cancer
NCT00964171 ·Status: COMPLETED ·Phase: PHASE2
-
Study of Low-Dose Fractionated Radiotherapy in Patients With Locally Advanced Metastatic Pancreatic Cancer
NCT00761345 ·Status: COMPLETED ·Phase: PHASE1
-
Study Assessing Safety and Efficacy of Combination of BL-8040 and Pembrolizumab in Metastatic Pancreatic Cancer Patients
NCT02826486 ·Status: COMPLETED ·Phase: PHASE2
-
Study of Personalized Tumor Vaccines (PCVs) and a PD-L1 Blocker in Patients With Pancreatic Cancer That Can be Treated With Surgery
NCT04161755 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Study of Single Agent Idelalisib Followed by Idelalisib in Combination With Chemotherapy in Adults With Metastatic Pancreatic Ductal Adenocarcinoma
NCT02468557 ·Status: TERMINATED ·Phase: PHASE1
-
Testing the Safety of the Anti-Cancer Drugs Durvalumab and Olaparib During Radiation Therapy for Locally Advanced Unresectable Pancreatic Cancer
NCT05411094 ·Status: RECRUITING ·Phase: PHASE1
-
Safety and Efficacy Study of Gemcitabine-erlotinib Versus Gemcitabine-erlotinib-capecitabine in Patients With Metastatic Pancreatic Cancer
NCT01303029 ·Status: COMPLETED ·Phase: PHASE2
-
A Maintenance Therapy Study of Odetiglucan With CDX-1140 in Patients With Metastatic Pancreatic Ductal Adenocarcinoma
NCT05484011 ·Status: TERMINATED ·Phase: PHASE1
-
Gemcitabine Hydrochloride, Dasatinib, and Erlotinib Hydrochloride in Treating Patients With Pancreatic Cancer That Is Metastatic or Cannot Be Removed by Surgery
NCT01660971 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
Phase 2, Nab Paclitaxel/Gemcitabine Alone and in Combination With ACP-196 in Subjects With Metastatic Pancreatic Cancer
NCT02570711 ·Status: TERMINATED ·Phase: PHASE2
-
A Phase 1 Study of Safety and Bioactivity With FG-3019 in Combination With Gemcitabine and Erlotinib for Subjects With Locally Advanced or Metastatic Pancreatic Cancer
NCT01181245 ·Status: COMPLETED ·Phase: PHASE1
-
MEDI9447(Oleclumab) Pancreatic Chemotherapy Combination Study.
NCT03611556 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Dinaciclib and Akt Inhibitor MK2206 in Treating Patients With Pancreatic Cancer That Cannot Be Removed by Surgery
NCT01783171 ·Status: COMPLETED ·Phase: PHASE1
-
Sorafenib With or Without Gemcitabine in Treating Patients With Metastatic Pancreatic Cancer
NCT00114244 ·Status: COMPLETED ·Phase: PHASE2
-
Combining Anti-PD-L1 Immune Checkpoint Inhibitor Durvalumab With TLR-3 Agonist Rintatolimod in Patients With Metastatic Pancreatic Ductal Adenocarcinoma for Therapy Efficacy
NCT05927142 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Siltuximab and Spartalizumab in Patients With Metastatic Pancreatic Cancer
NCT04191421 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
RAD001 in Previously Treated Patients With Metastatic Pancreatic Cancer
NCT00409292 ·Status: COMPLETED ·Phase: PHASE2