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Cardiac MRI in Measuring the Impact of Anti-androgen Treatment on Cardiac Function in Patients With Prostate Cancer

NCT02722525 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 23

Last updated 2026-03-23

No results posted yet for this study

Summary

Learning about the impact of anti-androgen treatment has on cardiac function in patients with prostate cancer may help plan treatment and help patients live more comfortably. This pilot clinical trial will utilize cardiac magnetic resonance imaging (MRI) before a patient starts hormone therapy and after 4 to 7 months of hormone therapy. The objective is to measure the impact of hormone therapy (anti-androgen treatment) on cardiac function in patients with prostate cancer.

Conditions

  • Cardiovascular Injury
  • Prostate Carcinoma

Interventions

PROCEDURE

Magnetic Resonance Imaging

Undergo treadmill stress CMR

BEHAVIORAL

Exercise Intervention

Complete treadmill exercise

PROCEDURE

Perfusion Magnetic Resonance Imaging

Undergo gadopentetate dimeglumine perfusion MRI

BEHAVIORAL

Exercise Intervention

Complete resistive lower extremity exercise

PROCEDURE

Spectroscopy

Undergo skeletal muscle PMRS

OTHER

Laboratory Biomarker Analysis

Correlative studies

Sponsors & Collaborators

  • Pelontonia

    collaborator UNKNOWN

  • Ohio State University Comprehensive Cancer Center

    lead OTHER

Principal Investigators

  • Steven Clinton, MD, PhD · Ohio State University Comprehensive Cancer Center

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-12-31
Primary Completion
2017-11-13
Completion
2026-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02722525 on ClinicalTrials.gov