Effect of 14 Day Bed Rest on Health Outcomes in Young and Older Participants

Summary

This investigation aimed to compare the response of older adult and young men to 14 day bed-rest and subsequent 28 day rehabilitation. Sixteen older (OM: 55-65 years) and seven young men (YM: 18-30 years) were exposed to 14-day bed rest (BR) followed by 14-day rehabilitation (R), and 400-day of R. Quadriceps muscle volume, force and explosive power of leg extensors, single fiber isometric force, peak aerobic power, gait stride length, and several metabolic were measured before and after BR and after R.

Conditions

• Muscular Atrophy

Interventions

BEHAVIORAL

physical inactivity or bed rest with supervised recovery

All (older and younger) participants underwent 14 day of horizontal bed rest with all 24 hour daily activities were performed lying in a bed. Maximal one pillow was allowed. 28-day supervised recovery was performed 3 times weekly for 75 minutes/session.

Sponsors & Collaborators

• University of Trieste

  collaborator OTHER

• University of Udine

  collaborator OTHER

• University of Padova

  collaborator OTHER

• Università degli Studi di Ferrara

  collaborator OTHER

• University of Nottingham

  collaborator OTHER

• DLR German Aerospace Center

  collaborator OTHER

• Izola General Hospital

  collaborator OTHER

• National Institute of Public Health, Slovenia

  collaborator OTHER_GOV

• University of Primorska

  lead OTHER

Principal Investigators

• Rado Pišot, PhD · University of Primorska, Slovenia

Study Design

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

MALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2012-08-31

Primary Completion

2014-01-31

Completion

2015-01-31

Countries

• Slovenia

Study Locations