Efficacy of ISST in Schizophrenia

Summary

The ISST study investigates whether integrated social cognitive remediation and social behavioral skills therapy is more efficacious in improving functional outcome and treatment adherence than an active control treatment comprising drill-and-practice oriented neurocognitive remediation.

Conditions

• Schizophrenia

Interventions

BEHAVIORAL

Integrated Social Cognitive and Behavioral Skills Therapy

The Integrated Social Cognitive and Behavioral Skills Therapy (ISST) is a newly developed treatment program. It is based on the Training of Affect Recognition (Wölwer et al. 2005) and common social skills trainings, which are combined in an integrated rather than a sequenced manner. ISST uses both repeated practice and strategy-based training, and consists of 12 individual sessions, 5 group sessions and 1 individual final session over a period of 6 months.

BEHAVIORAL

Neurocognitive Remediation Therapy

The Neurocognitive Remediation Program (NCRT) is based on a neurocognitive training already used as active control condition in our earlier studies (Wölwer et al. 2005, Klingberg et al. 2011). The present version of NCRT is matched in dose, mode and scheme of application to the ISST, but differs from the ISST regarding targeted cognitive domains and preferred training strategy (predominantly drill and practice based). The NCRT provides the same amount of group interaction and companionship as well as the same amount of guided community activity as in the ISST, but is structured in such a way that interactional behavior is secondary (e.g. by competition-like tasks rather than cooperative tasks). Thus therapeutic attention and commitment are held constant across study conditions.

Sponsors & Collaborators

• University Hospital, Bonn

  collaborator OTHER

• University Hospital of Cologne

  collaborator OTHER

• University Hospital Tuebingen

  collaborator OTHER

• Zentralinstitut für Seelische Gesundheit Mannheim

  collaborator OTHER

• University of Cologne

  collaborator OTHER

• Rheinhessen-Fachklinik Alzey

  collaborator OTHER

• Vivantes Klinikum am Urban

  collaborator UNKNOWN

• Heinrich-Heine University, Duesseldorf

  lead OTHER

Principal Investigators

• Wolfgang Wölwer, Prof. Dr. · Dept. of Psychiatry and Psychotherapy, University of Düsseldorf

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2016-03-31

Primary Completion

2021-02-28

Completion

2022-03-31

Countries

• Germany

Study Locations