Determinants of Quality Of Life in AGEd Cancer Patients

Summary

Patients face multiple stresses and challenges in the aftermath of cancer diagnosis. Despite needs perceived by elderly patients might differ from those of younger patients, there is a paucity of published data assessing the specific evolution and relevant determinants of health-related quality of life (HRQoL) in older patients with cancer. Such determinants may include cancer type/location/stage, treatment type/intensity, comorbidities, nutritional status or socioeconomic features, but also practical organization of care -frequency, geographical distance, supporting measures -, or psychosocial and material support - social network, housing conditions and contextual neighborhood features. Comparatively to dementia or cancer in younger patients, little is known in the oncogeriatric field of the impact on caregivers' perceived burden and HRQol of the support they provide to patients. Further, the potential interactions between patients' and caregivers' HRQoL remain largely unknown, while caregivers are often themselves old with chronic diseases and/or daily living activities' limitations.

The DEQOLAGE study is a prospective observational cohort study that aims to describe the HRQoL of patients aged over 70 years with a colorectal or prostatic cancer during the first year following the diagnosis of the disease as well as the HRQoL and burden in their main caregivers. This study will allow a comprehensive assessment of multiple determinants of HRQoL operating at different levels, including individual (cancer type/location/stage, treatment type/intensity, comorbidities, nutritional status or socioeconomic features), contextual (social network, housing conditions and contextual neighborhood features) and organizational factors (frequency, geographical distance, supporting measures). We also hypothesize that complex interactions may operate between patient's and caregiver's HRQoL and perceived burden. Quality of life measurement will be based on two recent scales specifically designed for the elderly to confirm their psychometric properties and in-field feasibility.

Conditions

• Colorectal Neoplasms
• Prostatic Neoplasms

Sponsors & Collaborators

• Paris 12 Val de Marne University

  collaborator OTHER

• Research Team APEMAC EA4360, University of Lorraine

  collaborator UNKNOWN

• Unité de Recherche Clinique Mondor, Hôpital Henri Mondor

  collaborator UNKNOWN

• Institut de Cancérologie de Lorraine

  collaborator OTHER

• Unité de Coordination en Onco-Gériatrie (UCOG) Sud Val-de-Marne

  collaborator UNKNOWN

• Quality of life and cancer clinical research platform

  collaborator UNKNOWN

• Ligue contre le cancer, France

  collaborator OTHER

• Conseil Régional de Lorraine, France

  collaborator UNKNOWN

• Assistance Publique - Hôpitaux de Paris

  lead OTHER

Principal Investigators

• Christine Perret-Guillaume · Central Hospital, Nancy, France

• Elena Paillaud · Hôpital Albert Chenevier

Eligibility

Min Age

70 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2016-02-29

Primary Completion

2019-02-28

Completion

2019-12-31

Countries

• France

Study Locations