A Study Using Regorafenib as Second or Third Line Therapy in Metastatic Medullary Thyroid Cancer
NCT02657551 · Status: ACTIVE_NOT_RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 8
Last updated 2025-09-11
Summary
This research study is studying a targeted therapy as a possible treatment for thyroid cancer. A targeted therapy is a type of treatment that uses drugs or other substances to identify and attack specific types of cancer cells with less harm to normal cells.
\- The name of the study intervention involved in this study is regorafenib.
Conditions
Interventions
- DRUG
-
Regorafenib is a small molecule inhibitor of multiple membrane-bound and intracellular kinases involved in normal cellular functions and in pathologic processes.
Sponsors & Collaborators
- collaborator INDUSTRY
- lead OTHER
Principal Investigators
-
Kartik Seghal, MD · Dana-Farber Cancer Institute
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2016-01-31
- Primary Completion
- 2025-12-31
- Completion
- 2025-12-31
Countries
- United States
Study Locations
More Related Trials
-
A Study of Sunitinib in Patients With Metastatic or Recurrent Thymic Carcinoma
NCT02623127 ·Status: COMPLETED ·Phase: PHASE2
-
Evaluating the Combination of Everolimus and Sorafenib in the Treatment of Thyroid Cancer
NCT01141309 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Sunitinib Malate in Treating Patients With Iodine-Refractory Recurrent or Metastatic Thyroid Cancer
NCT00519896 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of Continued Treatment With Regorafenib in Participants With Solid Tumors Who Have Participated in Other Bayer Studies
NCT06246643 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Daily Oral Regorafenib for Chemotherapy-Refractory, Metastatic and Locally Advanced Angiosarcoma
NCT02048722 ·Status: COMPLETED ·Phase: PHASE2
-
Thyroid Cancer and Sunitinib
NCT00510640 ·Status: COMPLETED ·Phase: PHASE2
-
Surufatinib as Neoadjuvant Treatment for Locally Advanced or Metastatic Differentiated Thyroid Cancer
NCT05989425 ·Status: RECRUITING ·Phase: PHASE2
-
Exploratory Study of Radium-223 and VEGF-Targeted Therapy in Patients With Metastatic Renal Cell Carcinoma and Bone Mets
NCT02406521 ·Status: COMPLETED ·Phase: PHASE1
-
Surufatinib in Combination With Tislelizumab in Subjects With Advanced Solid Tumors
NCT04579757 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Sunitinib Malate in Treating Patients With Thyroid Cancer That Did Not Respond to Iodine I 131 and Cannot Be Removed by Surgery
NCT00381641 ·Status: COMPLETED ·Phase: PHASE2
-
Regorafenib in Subjects With Gastrointestinal Stromal Tumors (GIST) Who Have Progressed After Standard Therapy
NCT01646593 ·Status: NO_LONGER_AVAILABLE
-
Observational Study Evaluating The Efficacy And Effects On Quality Of Life Of Targeted Treatments Following TKIs In mRCC
NCT02315755 ·Status: COMPLETED
-
Regorafenib in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor
NCT01068769 ·Status: COMPLETED ·Phase: PHASE2
-
Time Restricted Eating (TRE) in Metastatic Head and Neck Squamous Cell Cancer (mHNSCC) or Unresectable or Metastatic Renal Cell Carcinoma (RCC)
NCT06603155 ·Status: WITHDRAWN ·Phase: NA
-
Suberoylanilide Hydroxamic Acid in Treating Patients With Metastatic and/or Locally Advanced or Locally Recurrent Thyroid Cancer
NCT00134043 ·Status: COMPLETED ·Phase: PHASE2
-
Study of Sulfatinib in Treating Advanced Medullary Thyroid Carcinoma and Iodine-refractory Differentiated Thyroid Carcinoma
NCT02614495 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of Ramucirumab in Participants With Metastatic Renal Cell Carcinoma
NCT00515697 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase I/II Study to Assess the Safety and Efficacy of TKI258 for the Treatment of Refractory Advanced/Metastatic Renal Cell Cancer
NCT00715182 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of RO4929097 in Patients With Advanced Renal Cell Carcinoma That Have Failed Vascular Endothelial Growth Factor (VEGF)/Vascular Endothelial Growth Factor Receptor (VEGFR) Therapy
NCT01141569 ·Status: COMPLETED ·Phase: PHASE2
-
Study of Capecitabine in Metastatic Non-clear Cell Renal Cell Carcinoma (RCC) Patients
NCT01182142 ·Status: COMPLETED ·Phase: PHASE2
-
Regorafenib Phase I Study in Mainland Chinese Patients
NCT02398513 ·Status: COMPLETED ·Phase: PHASE1
-
A Study to Learn About the First and Later Lines of Medicines in Treating People With Metastatic Renal Cell Carcinoma (mRCC).
NCT05858749 ·Status: COMPLETED
-
Chemotherapy and Biological Therapy in Treating Patients With Locally Advanced or Metastatic Kidney Cancer
NCT00045370 ·Status: COMPLETED ·Phase: PHASE1
-
Pharmacokinetics and Safety of Regorafenib (BAY73-4506) in Cancer Subjects With Severe Renal Impairment
NCT01853046 ·Status: COMPLETED ·Phase: PHASE1
-
A Research Study for Patients With Metastatic Renal Cell Carcinoma
NCT00106613 ·Status: COMPLETED ·Phase: PHASE2