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pRotective vEntilation With Veno-venouS Lung assisT in Respiratory Failure

NCT02654327 · Status: UNKNOWN · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 1120

Last updated 2022-03-02

No results posted yet for this study

Summary

This is a trial of a new way of treating patients with respiratory failure. The investigators propose to deliver a multi-centre clinical trial to determine whether veno-venous extracorporeal carbon dioxide removal (VV-ECCO2R) and lower tidal volume mechanical ventilation improves outcomes and is cost-effective, in comparison with standard care in patients who are mechanically ventilated for acute hypoxaemic respiratory failure

Conditions

  • Acute Respiratory Failure With Hypoxia

Interventions

DEVICE

VV-ECCO2R to enable lower tidal volume mechanical ventilation

In the intervention arm a dual lumen catheter will be inserted into a central vein. VV-ECCO2R is commenced and managed as per study manual. Tidal volumes are then reduced on mechanical ventilation to enable lower tidal volume ventilation. Lower tidal volume facilitated by VV-ECCO2R will continue for a least 2 days up to a maximum of 7 days

Sponsors & Collaborators

  • Queen's University, Belfast

    collaborator OTHER

  • Northern Ireland Clinical Trials Unit

    collaborator OTHER

  • Belfast Health and Social Care Trust

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-05-12
Primary Completion
2020-03-12
Completion
2022-04-30

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02654327 on ClinicalTrials.gov