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Auto-antibodies Prevalence and CD1 Role in Gaucher Disease

NCT02650219 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2016-03-23

Study results available
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Summary

Hypergammaglobulinaemia is frequently observed in type 1 Gaucher disease (GD1), being either polyclonal or monoclonal gammopathies. Polyclonal hypergammaglobulinemia may be related to the presence of autoantibodies. The clinical significance of such antibodies is questioned in Gaucher disease (GD), as some cases of immunologic thrombocytopenia and autoimmune hemolytic anemia have also been reported.

Objectives:

To evaluate the prevalence of autoantibodies and autoimmune diseases in GD1 patients, we conducted a multicenter national study. The investigators investigated whether there was a link between splenectomy, genotype, therapeutic options and the presence of these autoantibodies.They also investigated whether there was a correlation with some clinical manifestations of GD1

Conditions

  • Gaucher Disease

Interventions

GENETIC

genetic analyses

Sponsors & Collaborators

  • Hospital St. Joseph, Marseille, France

    lead OTHER

Principal Investigators

  • Christine Serratrice, MD · St joseph France

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2010-01-31
Primary Completion
2015-12-31
Completion
2015-12-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02650219 on ClinicalTrials.gov