Microbiology of Para- og Retropharyngeal Abscess

Summary

The aims of the study are:

1. Explore the bacteriology of para- and retropharyngeal abscess.
2. Validate the bacterial findings by exploring antibody development against F. necrophorum, F. nucleatum and S. pyogenes.
3. Compare bacteriologic findings in concomitant peritonsillar and parapharyngeal abscesses.
4. Characterize patients with para- and retropharyngeal abscess.
5. Compare the concentration of amylase in para- and retropharyngeal abscesses and neck abscesses without relation to the pharynx or salivary glands.
6. Perform gene-sequencing of F. Necrophorum strains, and compare these with strains recovered from patients with acute tonsillitis, peritonsillar abscess, and Lemierre´s syndrome.

Conditions

• Retropharyngeal Abscess

Interventions

BIOLOGICAL

Bacteriology

Tonsillar surface swabs, tonsillar tissues, and pus aspirates.

PROCEDURE

Type of surgery

Surgical approach and complications.

BIOLOGICAL

Biochemistry

Amylase concentration i pus aspirates.

BIOLOGICAL

Serology

Levels of antibodies against selected bacteria (F. necrophorum, F. nucleatum, and Group A streptococci) in acute and convalescent sera.

Sponsors & Collaborators

• Hospitalsenheden Vest

  collaborator OTHER

• Aalborg University Hospital

  collaborator OTHER

• Sygehus Lillebaelt

  collaborator OTHER

• Aarhus University Hospital

  collaborator OTHER

• Statens Serum Institut

  collaborator OTHER

• University of Aarhus

  collaborator OTHER

• Odense University Hospital

  collaborator OTHER

• Tejs Ehlers Klug

  lead OTHER

Principal Investigators

• Tejs E Klug, MD · Aarhus University Hospital

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2016-04-30

Primary Completion

2020-01-31

Completion

2020-01-31

Countries

• Denmark

Study Locations