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The Clinical Relevance of Micro RNAs in Mild Traumatic Brain Injury

NCT02639923 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 155

Last updated 2026-04-22

No results posted yet for this study

Summary

The aim of this study is to investigate the early serum measurement (\<6h after injury) of mRNA miR Let-7i, miR-16 and miR-92 in patients with MHI and intracranial traumatic lesions (CCT pos.) as compared to those in patients with MHI without intracranial traumatic lesions (CCT neg.).

S100B serum levels will be measured in both groups. The usual risk factors for the occurrence of an intracranial hematoma (diagnostic algorithm) will be recorded. Additionally, a group of healthy individuals will serve as a control group.

During the study, technical and scientific capabilities and options increased and two further mRNA´S (miR-124-3p and miR-9-5p) will be investigated, too.

Conditions

  • Brain Injuries, Traumatic

Interventions

PROCEDURE

Drawing of 7ml peripheral blood

puncture peripheral vein

Sponsors & Collaborators

  • Medical Scientific Fund of the Mayor of Vienna

    collaborator OTHER

  • Harald Wolf, MD

    lead OTHER

Principal Investigators

  • Harald Wolf, M.D. · Department for Trauma Surgery, Medical University of Vienna

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-01-31
Primary Completion
2021-12-01
Completion
2021-12-01

Countries

  • Austria

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02639923 on ClinicalTrials.gov