A Study of Pembrolizumab for Patients With Thymic Epithelial Tumor
NCT02607631 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 33
Last updated 2020-07-09
Summary
This is a Phase II single center, open-label, single arm study in patients with advanced thymic epithelial tumors after failure of cisplatin-based combination chemotherapy. Patients will be treated with Pembrolizumab 200 mg every 3 weeks.
Conditions
- Thymic Epithelial Tumors
Interventions
- DRUG
-
treated with Pembrolizumab 200 mg every 3 weeks
Sponsors & Collaborators
-
Samsung Medical Center
lead OTHER
Principal Investigators
-
Myung-Ju Ahn, Prof. · Samsung Medical Center
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2015-11-30
- Primary Completion
- 2018-02-28
- Completion
- 2018-08-31
More Related Trials
-
Effect of Pembrolizumab With or Without Carboplatin and Paclitaxel on Immune Response in Patients With Recurrent or Stage IIIB-IV Non-small Cell Lung Cancer
NCT02581943 ·Status: COMPLETED ·Phase: PHASE2
-
A Trial of Pembrolizumab in Combination With Chemotherapy and Radiotherapy in Stage III NSCLC (KEYNOTE-799, MK-3475-799)
NCT03631784 ·Status: COMPLETED ·Phase: PHASE2
-
Immunotherapy as Second-line in Patient With Small Cell Lung Cancer
NCT03059667 ·Status: COMPLETED ·Phase: PHASE2
-
Study of Pembrolizumab (MK-3475) in Platinum Pre-treated Recurrent/Metastatic Nasopharyngeal Cancer (MK-3475-122/KEYNOTE-122)
NCT02611960 ·Status: COMPLETED ·Phase: PHASE3
-
A Study of Tiragolumab in Combination With Atezolizumab Plus Pemetrexed and Carboplatin/Cisplatin Versus Pembrolizumab Plus Pemetrexed and Carboplatin/Cisplatin in Participants With Previously Untreated Advanced Non-Squamous Non-Small Cell Lung Cancer
NCT04619797 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
A Study Evaluating the Efficacy and the Safety of First-line Chemotherapy Combined With the Therapeutic Vaccine Named TG4010 and Nivolumab in Patients With Advanced Non-squamous Non-Small Cell Lung Cancer (NSCLC)
NCT03353675 ·Status: COMPLETED ·Phase: PHASE2
-
Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158)
NCT02628067 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Pilot Study of PD-1inhibitor (Tislelizumab) Plus Chemotherapy as Neoadjuvant Therapy for Limited-Stage Small-Cell Lung Cancer
NCT04542369 ·Status: RECRUITING ·Phase: PHASE2
-
Study of Pembrolizumab (MK-3475) Subcutaneous (SC) Versus Pembrolizumab Intravenous (IV) Administered With Platinum Doublet Chemotherapy in Participants With Metastatic Squamous or Nonsquamous Non-Small Cell Lung Cancer (NSCLC) (MK-3475-A86)
NCT04956692 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Adjuvant Pembrolizumab in N2 Positive Non-small Cell Lung Cancer Patients
NCT03053856 ·Status: UNKNOWN ·Phase: PHASE2
-
Pembrolizumab and Paclitaxel in Refractory Small Cell Lung Cancer
NCT02551432 ·Status: COMPLETED ·Phase: PHASE2
-
Pembrolizumab With Nab-Paclitaxel in Non-Small Cell Lung Cancer
NCT02733250 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Postoperative Pembrolizumab for the Patients Who Have Solid Predominant or Micropapillary Lung Adenocarcinoma With Pathologic Stage I and Primary Tumor Than 4 cm
NCT03254004 ·Status: UNKNOWN ·Phase: PHASE2
-
Nivolumab Plus Cisplatin/Pemetrexed or Cisplatin/Gemcitabine as Induction in Resectable Non-Small Cell Lung Cancer
NCT03366766 ·Status: TERMINATED ·Phase: PHASE2
-
A Study of Nivolumab + Chemotherapy or Nivolumab + Ipilimumab Versus Chemotherapy in Non-Small Cell Lung Cancer (NSCLC) Participants With Epidermal Growth Factor Receptor (EGFR) Mutation Who Failed 1L or 2L EGFR Tyrosine Kinase Inhibitor (TKI) Therapy
NCT02864251 ·Status: COMPLETED ·Phase: PHASE3
-
A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%
NCT06561386 ·Status: RECRUITING ·Phase: PHASE3
-
Tabelecleucel in Combination With Pembrolizumab in Subjects With Epstein-Barr Virus-associated Nasopharyngeal Carcinoma (EBV+ NPC)
NCT03769467 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
A Study of Sargramostim Plus Pembrolizumab with or Without Pemetrexed in Patients with Advance Non-small Cell Lung Cancer After Completion of Chemoimmunotherapy
NCT04856176 ·Status: TERMINATED ·Phase: PHASE2
-
Study of Pembrolizumab (MK-3475) Monotherapy in Advanced Solid Tumors and Pembrolizumab Combination Therapy in Advanced Non-small Cell Lung Cancer/ Extensive-disease Small Cell Lung Cancer (MK-3475-011/KEYNOTE-011)
NCT01840579 ·Status: COMPLETED ·Phase: PHASE1
-
Pembrolizumab and Trametinib in Treating Patients With Stage IV Non-Small Cell Lung Cancer and KRAS Gene Mutations
NCT03299088 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of Tiragolumab Plus Atezolizumab Compared With Placebo Plus Atezolizumab in Participants With Completely Resected Non-small Cell Lung Cancer Who Have Received Adjuvant Platinum-based Chemotherapy
NCT06267001 ·Status: COMPLETED ·Phase: PHASE3
-
Pembrolizumab Every 12 Weeks Versus Every 3 Weeks in Treating Patients With Non-small Cell Lung Cancer
NCT04032418 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Low-Dose Interleukin-2 and Pembrolizumab for the Treatment of Stage IV Non-Small Cell Lung Cancer
NCT05493566 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Study Evaluating Effectiveness and Safety of Zimberelimab and Domvanalimab in Lung Cancer
NCT04736173 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Efficacy and Safety of Pembrolizumab (MK-3475) With Platinum Doublet Chemotherapy as Neoadjuvant/Adjuvant Therapy for Participants With Resectable Stage II, IIIA, and Resectable IIIB (T3-4N2) Non-small Cell Lung Cancer (MK-3475-671/KEYNOTE-671)
NCT03425643 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3