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Genetic and Environmental Determinants That Control Metabolism in Pulmonary Hypertension

NCT02594917 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 13

Last updated 2023-09-22

No results posted yet for this study

Summary

The investigators are performing this research study to determine whether having low iron-sulfur cluster levels can cause a disease known as pulmonary hypertension (PH). PH is defined as abnormally high blood pressure in the arteries of the lungs.

Usually, small specialized structures inside each human cell called mitochondria are in charge of generating energy within lung arteries for normal function. During situations of disease or stress, lung arteries undergo a change in the function of mitochondria, resulting in the development of PH. In studies on mice, investigators have learned that alterations in the production of specific metal complexes called iron-sulfur clusters are responsible for these changes. This makes it more likely that mice will develop PH.

In this study, the investigators want to find out if alteration of iron-sulfur cluster formation leads to increased likelihood of developing PH in humans.

Conditions

  • Iron-sulfur Cluster Deficiency
  • Pulmonary Hypertension
  • Friedreich Ataxia

Interventions

PROCEDURE

Right Heart Catheterization

Some participants (i.e., those that are willing and able) will undergo a Right Heart Catheterization to check Cardiopulmonary function.

OTHER

Blood draw

Test and control group will be asked to give 20 ml of blood samples

Sponsors & Collaborators

  • University of Pittsburgh

    lead OTHER

Principal Investigators

  • Stephen Chan, MD, PhD, FAHA · University of Pittsburgh

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-10-31
Primary Completion
2023-09-01
Completion
2023-09-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02594917 on ClinicalTrials.gov