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Analysis of Oral Mucositis in Patient's Undergoing Melphalan Conditioning and Autologous Stem Cell Transplant

NCT02589860 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2022-01-10

No results posted yet for this study

Summary

This is a pilot study to explore and identify changes in molecular processes within the oral mucosa that are associated with the development of oral mucositis (OM) in patients treated with Melphalan who undergo autologous peripheral blood stem cell transplantation.

Conditions

Interventions

OTHER

Melphalan kinetic study

Concentration of Melphalan in plasma samples

GENETIC

Oral bacterial study

DNA from oral buccal mucosal cells will be sequenced for bacterial composition

GENETIC

Gene expression study

RNA from oral buccal mucosal cells will be analyzed to compare gene expression

Sponsors & Collaborators

  • Sherif S. Farag

    lead OTHER

Principal Investigators

  • Sheriff Farag, M.D., Ph.D. · Indiana University School of Medicine, Indiana University Simon Cancer Center

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-10-30
Primary Completion
2020-03-23
Completion
2020-03-23

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02589860 on ClinicalTrials.gov