Trial of Adoptive T Cell Therapy With Activated P53 Specific T Cells for Treatment of Advanced Colorectal Cancer
NCT02577588 · Status: TERMINATED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 1
Last updated 2018-04-11
Summary
The study "Phase I trial of Adoptive T cell Therapy with Activated P53 specific T cells for Treatment of Advanced Colorectal Cancer" is an open label, single arm trial.
Conditions
- Colorectal Carcinoma
Interventions
- BIOLOGICAL
-
re-activated T cells
autologous reactivated T cells against p53
Sponsors & Collaborators
-
German Cancer Research Center
collaborator OTHER -
University Hospital Heidelberg
collaborator OTHER -
National Center for Tumor Diseases, Heidelberg
lead OTHER
Principal Investigators
-
Alexis Ulrich, MD Prof. Dr. · University Hospital Heidelberg
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2016-05-01
- Primary Completion
- 2018-02-19
- Completion
- 2018-02-19
Countries
- Germany
Study Locations
More Related Trials
-
Immunotherapy In Locally Advanced Rectal Cancer
NCT03854799 ·Status: COMPLETED ·Phase: PHASE2
-
High-activity Natural Killer Immunotherapy for Small Metastases of Colorectal Cancer
NCT03008499 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Expression of Molecular Markers Before and After Neo-adjuvant Chemoradiotherapy in Rectal Cancer
NCT00835055 ·Status: WITHDRAWN
-
Study on the Safety and Tolerability of PD-1 Knockout Tumor-infiltrating T Cells (TILs) in the Treatment of Advanced Colorectal Cancer
NCT07035002 ·Status: RECRUITING ·Phase: PHASE1
-
Efficacy of Adjuvant Cytokine-induced Killer Cells in Colon Cancer
NCT01929499 ·Status: UNKNOWN ·Phase: PHASE2
-
Neoantigen-based Peptide Vaccine and Conventional Third-line Therapy for CRC Progressed After Second-line Treatment
NCT06751966 ·Status: RECRUITING ·Phase: NA
-
Immune Checkpoints in Predicting Response to Neoadjuvant Therapy in Rectal Cancer
NCT05457075 ·Status: COMPLETED
-
Neoadjuvant Radiation Therapy and Capecitabine in Treating Patients With Stage III or Stage IV Colorectal Adenocarcinoma
NCT00075556 ·Status: UNKNOWN ·Phase: PHASE2
-
Watch and Wait as Treatment for Patients With Rectal Cancer
NCT03125343 ·Status: RECRUITING ·Phase: NA
-
Studying Biomarkers in Tumor Tissue and Blood Samples From Patients Undergoing Chemotherapy and Radiation Therapy for Stage II or Stage III Rectal Cancer That Can Be Removed By Surgery
NCT00960427 ·Status: WITHDRAWN ·Phase: PHASE1
-
Curative Proton Beam Therapy for Patients With Liver Metastasis of Colorectal Cancer
NCT03577665 ·Status: RECRUITING ·Phase: NA
-
Talimogene Laherparepvec, Chemotherapy, and Radiation Therapy Before Surgery in Treating Patients With Locally Advanced or Metastatic Rectal Cancer
NCT03300544 ·Status: TERMINATED ·Phase: PHASE1
-
DC-CIK Immunotherapy Plus Chemotherapy vs Chemotherapy Alone in the Adjuvant Treatment of Stage III Colorectal Cancer
NCT02415699 ·Status: UNKNOWN ·Phase: PHASE2/PHASE3
-
Avoiding Surgery in Rectal Cancer After Pre-Operative Therapy
NCT01047969 ·Status: UNKNOWN ·Phase: PHASE2
-
Phase II Study of Maintenance Capecitabine to Treat Resectable Colorectal Cancer
NCT01880658 ·Status: UNKNOWN ·Phase: PHASE2
-
Concurrent Chemo-proton Radiotherapy With or Without Resection and Spacer Insertion for Loco-regional Recurrence of Previous Irradiated Rectal Cancer
NCT03098108 ·Status: UNKNOWN ·Phase: NA
-
Efficacy Study of TKcell in Advanced Colorectal Cancer
NCT00854971 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Study of High-Dose-Rate Endorectal Brachytherapy (HDRBT) in the Treatment of Locally Advanced Low Rectal Cancer
NCT01226979 ·Status: COMPLETED ·Phase: NA
-
Can We Save the Rectum by Watchful Waiting or TransAnal Surgery Following (chemo)Radiotherapy Versus Total Mesorectal Excision for Early REctal Cancer?
NCT02945566 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2/PHASE3
-
Anti-PD-1 Antibody Combined With Autologous DC and NK Cells in the Treatment of Digestive Carcinoma
NCT05461235 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Gastrointestinal Cancer
NCT00025532 ·Status: WITHDRAWN ·Phase: PHASE1
-
Biological Therapy and Chemotherapy in Treating Patients With Metastatic Kidney Cancer or Colorectal Cancer
NCT00030342 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Exploring the Treatment Duration of PD-1 Neoadjuvant Therapy in Stage II-III dMMR Rectal Cancer
NCT06613165 ·Status: RECRUITING
-
PD1 Antibody Toripalimab and Chemoradiotherapy for dMMR/MSI-H Locally Advanced Colorectal Cancer
NCT04301557 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Resource-Sparing Curative Treatment for Rectal Cancer
NCT01459328 ·Status: UNKNOWN ·Phase: PHASE3