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Thalamic Deep Brain Stimulation for Spasmodic Dysphonia- DEBUSSY Trial

NCT02558634 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 6

Last updated 2022-06-14

Study results available
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Summary

Laryngeal Dystonia (LD), also commonly referred to as spasmodic dysphonia, is a neurological voice disorder characterized by involuntary dystonic contractions of the laryngeal muscles. Current treatments such as botox and voice therapy only provide temporary relief and thus, the investigators are exploring new strategies to provide long-term, sustained improvement.

Deep Brain Stimulation (DBS) is a neurosurgical procedure that involves the implantation of electrodes to deliver electrical stimuli to specific brain regions. It is the standard surgical treatment for many other movement disorders such as Parkinson's disease, essential tremor, and primary dystonia. This trial has been designed to test the hypothesis that DBS can improve the vocal dysfunction of LD.

Conditions

  • Spasmodic Dysphonia
  • Laryngeal Dystonia
  • Deep Brain Stimulation

Interventions

DEVICE

VIM Thalamic Deep Brain Stimulation ON

DEVICE

VIM Thalamic Deep Brain Stimulation OFF

Sponsors & Collaborators

  • University of British Columbia

    lead OTHER

Principal Investigators

  • Christopher R Honey, MD, DPhil · UBC

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-01-31
Primary Completion
2019-05-31
Completion
2020-03-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02558634 on ClinicalTrials.gov