The Efficacy and Mechanisms of Oral Probiotics in Preventing Necrotizing Enterocolitis

Summary

The purpose of this study is to investigate the efficacy and its mechanisms of oral mixture probiotics in preventing necrotizing enterocolitis among the preterm very low birth weight infants.

Conditions

• Necrotizing Enterocolitis
• Death

Interventions

DIETARY_SUPPLEMENT

probiotics

Administration of mixture probiotics 500mg by mouth, one time or divided into 2-4 times depends on the feeding volume until to 36 weeks post menstrual age.

DIETARY_SUPPLEMENT

glucose solution

Administration of 1 mL of a 5% glucose solution by mouth, one time or divided into 2-4 times depends on the feeding volume until to 36 weeks post menstrual age.

Sponsors & Collaborators

• China Medical University Hospital

  collaborator OTHER

• Shenzhen People's Hospital

  collaborator OTHER

• Shenzhen Sixth People's Hospital

  collaborator OTHER

• Longhua Hospital Of Baoan District, Shenzhen

  collaborator OTHER

• Shenzhen Bao'an Maternal and Child Health Hospital

  lead OTHER

Principal Investigators

• Yuefeng Li, M.D. · Shenzhen Bao'an Maternal and Child Health Hospital

• HungChih Lin, M.D. · China Medical University Hospital

• Benqing Wu, M.D. · Shenzhen People's Hospital

• Xiaodong Li, M.D. · Shenzhen Sixth People's Hospital

• Zhangxin Wang, M.D. · Longhua Hospital Of Baoan District, Shenzhen

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Model

PARALLEL

Eligibility

Max Age

3 Days

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2014-09-30

Primary Completion

2017-01-31

Completion

2017-09-30

Countries

• China

Study Locations