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The Role of the Coagulation Pathway at the Synapse in Prion Diseases

NCT02480725 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2015-06-24

No results posted yet for this study

Summary

The study hypothesis is that that the deleterious effect of prions on the brain may be mediated (at least partially) by activation of serine proteases involved in the coagulation system. If this is true, then measurement of the activity of the coagulation system may be a marker of disease onset (in at higher risk individuals such as E200K\* carriers) and for disease progression or activity in affected individuals. In addition, modulation of the coagulation system activity may be a potential tool for therapeutic intervention.

\*E200K- E200K mutation (Glu to Lys substitution) in the prion protein gene

Conditions

  • Creutzfeldt-Jakob Syndrome

Interventions

PROCEDURE

collect CSF (Cerebrospinal fluid) sample

collecting CSF samples for thrombin activity assay

Sponsors & Collaborators

  • Prof. Zerr , Prion Referral Center , University of Gottingen, Germany

    collaborator UNKNOWN

  • Sheba Medical Center

    lead OTHER_GOV

Principal Investigators

  • Oren Cohen, Dr. (MD) · Cheba Medical Center

Eligibility

Min Age
35 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-06-30
Primary Completion
2024-07-31
Completion
2025-07-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02480725 on ClinicalTrials.gov