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The Link Between BRCA Mutation and Endothelial Function

NCT02474264 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 82

Last updated 2017-07-18

No results posted yet for this study

Summary

This study evaluates the effect of BRCA1\&2 mutations on cardiovascular diseases by to comparing the endothelial function of male BRCA mutation carriers with that of age matched non-BRCA mutation carriers.

Conditions

  • BRCA1 Gene Mutation
  • BRCA2 Gene Mutation

Interventions

OTHER

Endothelial function assessment

reactive hyperemia index

OTHER

Cardiovascular biomarkers

Cardiovascular biomarkers will be measure to test other aspects of endothelial and cardiac function: high-sensitivity troponin (hsTn) , C-reactive protein , D-dimer, N-terminal pro-brain natriuretic peptide (NT-proBNP)

OTHER

Endothelial cells

Endothelial Progenitor Cells and Circulating Endothelial Cells profiles- will be characterized to evaluate endothelial injury.

Sponsors & Collaborators

  • Rabin Medical Center

    lead OTHER

Principal Investigators

  • David Margel, MD, PhD · Rabn Medical Center, Beilinson Campus

Study Design

Allocation
NON_RANDOMIZED
Purpose
SCREENING
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-02-28
Primary Completion
2018-07-31
Completion
2018-11-30

Countries

  • Israel

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02474264 on ClinicalTrials.gov