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Virtual Coronary Physiology: an Angiogram is All You Need

NCT02437734 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 119

Last updated 2017-04-25

No results posted yet for this study

Summary

Disease in coronary arteries kills more people in the UK than any other cause. The investigators have developed a computer system ('VIRTU') which predicts blood pressure changes inside coronary arteries. This is important because;

* Doctors make better decisions regarding when and how to treat patients with coronary artery disease if they have these blood pressure measurements
* Currently, Doctors have to insert a metal wire inside the heart to measure artery pressures which is time-consuming and requires special equipment, staff, training and medicines.

Although this invasive technique saves lives and money, more than 95% of patients do not receive the procedure or the benefits it provides.

VIRTU provides a solution to this problem since it only needs X-ray pictures and does not require any wires, drugs, or additional time, equipment or staff. VIRTU has been tested and works but needs improving before it can be used in all patients.

GOALS:

Following, and compared with, our pilot project ((Modelling the significance of coronary artery disease, STH 15740) to:

1. Improve VIRTU's accuracy.
2. Improve VIRTU's speed.
3. Test VIRTU in patients with more complicated coronary disease.

One hundred patients will be recruited from angiography waiting lists and consented before attending for their angiography. The patients will be asked whether their angiogram pictures and pressure measurements maybe used as part of the data collection for this study. The data will be used to validate and develop VIRTU to make it 'patient-ready'. VIRTU will deliver all the advantages of the current invasive technique (i.e. reduced deaths, heart attacks and cost) but, is less invasive and usable in 100% patients.

Conditions

Interventions

PROCEDURE

Percutaneous Coronary Intervention

A phase II, observational, analytical study of coronary angiography and computational fluid dynamics in 100 adults with coronary artery disease undergoing coronary angiography.

Sponsors & Collaborators

  • Wellcome Trust

    collaborator OTHER

  • Sheffield Teaching Hospitals NHS Foundation Trust

    lead OTHER

Principal Investigators

  • Nana Theodorou · STH

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-08-13
Primary Completion
2016-10-31
Completion
2016-10-31

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02437734 on ClinicalTrials.gov