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In Vitro Models of Liver and Pancreatic Cancer

NCT02436564 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 75

Last updated 2016-07-14

No results posted yet for this study

Summary

The primary objective is to develop an in vitro model of cancer for laboratory study using liver, biliary and pancreatic cancer tissue. The secondary objective is to study the genetic and cellular biology of cancer of the liver, biliary tract and the pancreas. As well the investigators hope to compare molecular and cellular biology of cancer cells with normal cells as well as potentially test the efficacy of current and future anti-cancer therapies.

Samples will be collected from tissue that has been resected as part of the treatment for a patient diagnosed with liver, bile duct or pancreas cancer.

Conditions

Interventions

GENETIC

Organoid in vitro culture

Generation of 'organoids' using in vitro culture techniques, genomic DNA and RNA sequencing, application of genome editing technology, investigation of anti-tumour drugs, investigation of biological and functional properties of tumour cells, transplantation of organoid lines into animal models.

Sponsors & Collaborators

  • The Gurdon Institute

    collaborator UNKNOWN

  • Ann McLaren Laboratory of Regenerative Medicine

    collaborator UNKNOWN

  • Cambridge University Hospitals NHS Foundation Trust

    lead OTHER

Principal Investigators

  • Kourosh Saeb-Parsy, PhD, FRCS · Cambridge Univeristy Hospitals

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-07-31
Primary Completion
2018-09-30

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02436564 on ClinicalTrials.gov