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Effect of a GnRH Injection on Ghrelin Concentrations in Girls With Suspected Premature Puberty

NCT02431416 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 13

Last updated 2019-04-01

No results posted yet for this study

Summary

The purposes of the study is to investigate whether circulating levels of ghrelin decreases after an iv injection of GnRH in girls with suspected central premature puberty and to investigate the effects of different post sampling handling on the preservation of acylated ghrelin.

Conditions

  • Puberty, Precocious

Interventions

DRUG

Gonadotropin releasing hormone (GnRH)

Gonadotropin releasing hormone GnRH (Relefact LHRH) iv injection, single dose, 100 micrograms/square meter body surface, maximum dose: 100 microgram.

DRUG

Sodium Chloride

Sodium chlorid 9 mg/mL will be given as a single iv injection with the same volume as the volume used for the active substance injection.

Sponsors & Collaborators

  • Uppsala-Örebro Regional Research Council

    collaborator OTHER

  • Region Örebro County

    lead OTHER

Principal Investigators

  • Maria Lodefalk, MD, PhD · Department of Paediatrics, Faculty of Medicine and Health, Örebro University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
1 Year
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-05-31
Primary Completion
2017-12-31
Completion
2018-09-30

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02431416 on ClinicalTrials.gov