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Expression of IFN-epsilon in the Female Reproductive Tract

NCT02416154 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 32

Last updated 2021-12-27

No results posted yet for this study

Summary

The proposed study aims to determine the expression of Interferon-ε (IFNε) in the female genital tract, which has never been mapped before in humans. High expression in other mammalian female reproductive tract (FRT) has been suggested to be important in anti-sexually transmitted infection (STI)/HIV immunity and its expression decreases with progestogen treatment. Future studies are planned to understand if hormonal contraceptives affect the presence of interferon in the healthy female genital tract, potentially changing the risk of for STI and HIV.

Conditions

  • Interferon Expression in the Female Reproductive Tract

Interventions

PROCEDURE

Reproductive tract and blood sampling

Reproductive tract and blood sampling will be performed at enrollment only in this cross-sectional parallel cohort study.

Sponsors & Collaborators

  • Bill and Melinda Gates Foundation

    collaborator OTHER

  • MIMR-PHI Institute, Australia

    collaborator UNKNOWN

  • University of Pittsburgh

    lead OTHER

Principal Investigators

  • Paul Hertzog, PhD · Hudson Institute of Medical Research

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-07-31
Primary Completion
2016-07-31
Completion
2020-05-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02416154 on ClinicalTrials.gov