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Changes of microRNA Expression in Obstructive and Neurogenic Bladder Dysfunction

NCT02410876 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2021-04-29

No results posted yet for this study

Summary

Patients with obstructive or neurogenic lower urinary tract disease will be invited to participate. Upon agreement they will undergo an assessment of bladder function (questionnaires) and bladder biopsies at 2 time-points. Bladder biopsies will be evaluated for molecular changes in the laboratory and compared to the functional findings.By uncovering the molecular similarities and differences between BLUTD and NLUTD, the investigators will elucidate some of the causative factors in the development of these disorders and highlight the impact of myogenic and neurogenic components postulated to be involved. The project involves close collaboration between clinical and basic research.

Conditions

  • Disorder of the Lower Urinary Tract

Interventions

PROCEDURE

Bladder biopsy

Small biopsy of the bladder is taken with cold-cup tongs.

PROCEDURE

Urodynamic study

Assessment of bladder function through intravesical and intrabdominal pressure measurements according to International Continence Society standards.

Sponsors & Collaborators

  • Swiss National Science Foundation

    collaborator OTHER

  • Balgrist University Hospital

    collaborator OTHER

  • Insel Gruppe AG, University Hospital Bern

    lead OTHER

Principal Investigators

  • Fiona C Burkhard, MD · Insel Gruppe AG, University Hospital Bern

  • Jürgen Pannek, MD · Swiss paraplegic center Nottwil

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-06-30
Primary Completion
2020-12-31
Completion
2020-12-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02410876 on ClinicalTrials.gov