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Muscle Ultrasound Measures as Biomarkers of Upper Motor Neuron Function

NCT02408900 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 15

Last updated 2019-12-17

No results posted yet for this study

Summary

Background:

\- Primary lateral sclerosis (PLS) is a rare disease. It leads to weakness in the muscle of the arms, legs, and face. People with PLS develop muscle stiffness called spasticity. Researchers want to find a better way to measure this. They want to see if ultrasound, which uses sound waves to look at parts of the body, can measure spasticity and stiffness in muscles.

Objective:

\- To see if ultrasound can detect and measure muscle spasticity in people with PLS.

Eligibility:

* People ages 18 75 who have a diagnosis of PLS and are enrolled in protocol 01-N-0145.
* Healthy volunteers ages 18 75.

Design:

* Participants with PLS will have 1 study visit. Healthy participants will have upto 5 visits. Each visit will be about 2 hours.
* Participants will have tests of muscle strength. They will be examined. They will push their arms and legs against researchers in different positions.
* Participants will have tests of muscle stiffness. Their arms and legs will be moved while they relax.
* Participants will have a muscle ultrasound test. They will lie on a table. Gel will be placed on the skin over the muscles of the arms and legs. A probe, like a microphone, will be moved over the skin. Researchers will look at several muscles.
* Participants should try to stay still during the ultrasound. It may be done several times and may be done by different examiners.

Conditions

  • Muscle Spasticity

Sponsors & Collaborators

  • National Institute of Neurological Disorders and Stroke (NINDS)

    lead NIH

Principal Investigators

  • Mary Kay Floeter, M.D. · National Institute of Neurological Disorders and Stroke (NINDS)

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-03-25
Primary Completion
2015-08-03
Completion
2015-08-03

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02408900 on ClinicalTrials.gov