MedTrace Logo

Bacterial Transmission Dynamics Study

NCT02401204 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 97

Last updated 2019-09-11

No results posted yet for this study

Summary

Infections with multiply antibiotic-resistant bacteria represent a major cause of preventable morbidity and mortality amongst hospitalized neonates worldwide. In Southeast Asia, where antibiotic-resistance is a major problem, Gram-negative bacteria account for the majority of such infections. The most common pathogens are Acinetobacter spp., Pseudomonas aeruginosa, Enterobacter spp., Escherichia coli and Klebsiella pneumonia. The great majority of infections with these pathogens represent asymptomatic carriage, though in the absence of routine screening for asymptomatic carriage reliable estimates of the prevalence, rates of transmission between patients, and rates of importation from the community are lacking. Moreover, current understanding of the degree and manner in which different antibiotics act to select for such resistant organisms is rudimentary.

Conditions

  • Bacterial Transmission Surveillance
  • Neonatal Intensive Care Unit
  • Drug Resistance

Interventions

OTHER

Longitudinal surveillance study

Regular specimens will be routinely collected as standard of practice. A rectal swab and stool specimen will be collected twice a week since first admission on NICU until discharge from NICU. If participant is intubated/ventilated, a throat swab will be collected.

Sponsors & Collaborators

  • Mahidol Oxford Tropical Medicine Research Unit

    collaborator OTHER

  • Queen Sirikit National Institute of Child Health

    collaborator OTHER_GOV

  • University of Oxford

    lead OTHER

Principal Investigators

  • Ben Cooper, Dr. · Mahidol Oxford Tropical Medicine Research Unit

Eligibility

Max Age
1 Month
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-02-28
Primary Completion
2019-05-31
Completion
2019-05-31

Countries

  • Thailand

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02401204 on ClinicalTrials.gov