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Effect of Remote Ischemic Preconditioning on Postoperative Complications in Visceral Surgery

NCT02375269 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 526

Last updated 2015-03-02

No results posted yet for this study

Summary

Remote Ischemic Preconditioning (RIPC) is mediated by intermittent brief episodes (5-10 minutes) of short ischemia in a limb (i.e. arm), followed by reperfusion. For this purpose in 3-4 cycles, a tourniquet is insufflated to suprasystolic pressure levels for 5 minutes and deflated for 5 minutes afterwards. The ischemic episodes are known to stimulate platelets and factors platelet dependent factors such as Serotonin and VEGF. These humoral factors have a systemic effect and have the potential to protect target organs (i.e. heart, kidney, liver) remote to the ischemic limb.

The purpose of this randomized controlled study is to investigate the influence and impact of RIPC on postoperative complications in patients undergoing visceral surgery

Conditions

  • Postoperative Complication

Interventions

DEVICE

RIPC with a tourniquet

Sponsors & Collaborators

  • University of Zurich

    lead OTHER

Principal Investigators

  • Pierre- Alain Clavien, MD, Phd · Department of Surgery, Swiss HPB and Transplant Surgery, University Hospital Zurich, Switzerland

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-03-31
Primary Completion
2018-03-31
Completion
2018-03-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02375269 on ClinicalTrials.gov